Is Asymmetric Dimethylarginine a Useful Biomarker in Children With Carbon Monoxide Poisoning?

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dc.contributor.authorYazar, Abdullah
dc.contributor.authorAkin, Fatih
dc.contributor.authorSert, Ahmet
dc.contributor.authorTure, Esra
dc.contributor.authorTopcu, Cemile
dc.contributor.authorYorulmaz, Alaaddin
dc.contributor.authorErcan, Fatih
dc.date.accessioned2024-02-23T14:21:17Z
dc.date.available2024-02-23T14:21:17Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective Carbon monoxide poisoning (COP) is the leading cause of mortality and morbidity due to poisoning worldwide. Because children are affected more quick and severely from COP, they may require a longer treatment period, even if carboxyhemoglobin (CO-Hb) and/or lactate levels return to normal. Therefore, a new marker that predicts the duration of treatment and the final outcomes of COP is needed. Methods This case control study was conducted on 32 carbon monoxide-poisoned patients younger than 18 years who had been admitted to pediatric emergency department. The control group included age- and sex-matched 30 healthy children. Blood samples were obtained for analysis of arterial blood gases, CO-Hb percent, methemoglobine, lactate, and asymmetric dimethylarginine (ADMA). Results Asymmetric dimethylarginine levels were significantly increased (P < 0.05) in patients with COP on admission and after the treatment when compared with controls (1.36 [0.89-6.94], 1.69 [0.76-7.81], 1.21 [0.73-3.18] nmol/L, respectively). There was no positive correlation between CO-Hb and ADMA levels on admission and at 6 hours (P = 0.903, r = 0.218, P = 0.231, r = 0.022, respectively). Positive correlation was found between lactate and CO-Hb levels on admission (P = 0.018, r = 0.423). Conclusions This study showed that ADMA levels were still high after 6 hours of 100% oxygen therapy in children with COP, even CO-Hb and/or lactate levels return to normal range. On the basis of these results, we consider that ADMA may be a useful biomarker in patient with COP.en_US
dc.identifier.doi10.1097/PEC.0000000000001758
dc.identifier.endpage230en_US
dc.identifier.issn0749-5161
dc.identifier.issn1535-1815
dc.identifier.issue3en_US
dc.identifier.pmid30747788en_US
dc.identifier.scopus2-s2.0-85062425417en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://doi.org/10.1097/PEC.0000000000001758
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13532
dc.identifier.volume35en_US
dc.identifier.wosWOS:000462638500019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPediatric Emergency Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdmaen_US
dc.subjectBiomarkeren_US
dc.subjectCarbon Monoxideen_US
dc.titleIs Asymmetric Dimethylarginine a Useful Biomarker in Children With Carbon Monoxide Poisoning?en_US
dc.typeArticleen_US

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