Serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine levels, and histopathologic examination of the abdominal aorta in rats exposed to acrylamide

Basit Öğe Kaydı
dc.contributor.authorToker, A.
dc.contributor.authorYerlikaya, F. H.
dc.contributor.authorYener, Y.
dc.contributor.authorToy, H.
dc.date.accessioned2024-02-23T14:34:37Z
dc.date.available2024-02-23T14:34:37Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractWe investigated serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine (ADMA) levels and conducted a histopathologic examination of the abdominal aorta in rats given acrylamide (AA) for long periods. We used 25 male and 25 female Wistar rats. Females were divided into three groups; two were experimental groups and one was the control group. Each experimental group consisted of ten animals and each control group consisted of five animals; male animals were divided in the same way. AA, 2 or 5 mg/kg/day, was administered to the experimental groups in drinking water for 90 days. At the end of the experiment, serum samples were analyzed for homocysteine, arginine, citrulline and ADMA using high performance liquid chromatography. Serum homocysteine, citrulline and ADMA levels were significantly higher than controls in both female and male rats when AA was administered at a concentration of 5 mg/kg/day. Serum citrulline levels also were significantly higher than controls when administered AA at a concentration of 2 mg/kg/day in female rats. There was no difference in serum arginine levels among the groups. Histopathologic examination of the abdominal aorta revealed degeneration of the external elastic lamina in rats treated with 5 mg/kg/day AA. Our findings show that long term ingestion of high dose AA with food might contribute to the development of atherosclerosis.en_US
dc.identifier.doi10.3109/10520295.2012.745950
dc.identifier.endpage108en_US
dc.identifier.issn1052-0295
dc.identifier.issue2en_US
dc.identifier.pmid23244234en_US
dc.identifier.scopus2-s2.0-84872354787en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.745950
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15671
dc.identifier.volume88en_US
dc.identifier.wosWOS:000321903600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectAbdominal Aortaen_US
dc.subjectArginineen_US
dc.subjectAsymmetric Dimethyl Arginineen_US
dc.subjectCitrullineen_US
dc.subjectHomocysteineen_US
dc.titleSerum homocysteine, arginine, citrulline and asymmetric dimethyl arginine levels, and histopathologic examination of the abdominal aorta in rats exposed to acrylamideen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu