Serum leptin level and waist-to-hip ratio (WHR) predict the overall survival of metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs)
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Japan Kk
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs). Sixty MBC patients treated with first line hormonal therapy were enrolled in this study. Median age was 51 years (range 28-75). Median leptin level was 19400 pg/ml (1970-91900) and estradiol level 29.6 pg/ml (4.0-181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was a parts per thousand yen19400 pg/ml (HR = 0.38; 95% CI: 0.16-0.91). This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.
Açıklama
46th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) -- JUN 04-08, 2010 -- Chicago, IL
Anahtar Kelimeler
Metastatic Breast Cancer, Leptin, Waist-To-Hip Ratio, Weight, Aromatase Inhibitors, Hormonal Therapy
Kaynak
Breast Cancer
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
20
Sayı
2
