Changes in Liver Tissue Trace Element Concentrations During Hepatitis B Viral Infection Treatment

Basit Öğe Kaydı
dc.contributor.authorSahin, Memduh
dc.contributor.authorKarayakar, Fahri
dc.contributor.authorKoksal, Ali Riza
dc.contributor.authorYetim, Aylin
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorSen, Ilker
dc.contributor.authorAlkim, Hueseyin
dc.date.accessioned2024-02-23T13:59:43Z
dc.date.available2024-02-23T13:59:43Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractApproximately 350-400 million people in the world have Hbs Ag (hepatitis B virus surface antigen) positivity. In the international guidelines, the permanent suppression of replication in chronic hepatitis B virus (HBV) infection therapy is reported as the primary therapeutic goal. Trace elements play a key role in liver diseases. The aim of our study is to determine some trace element concentrations in the liver during HBV treatment periods. The measurement of 11 trace elements (manganese, lead, nickel, chromium, cadmium, iron, copper, zinc, silver, cobalt, and aluminum) was carried out by the method of inductively coupled plasma mass spectrometry in liver biopsy materials (before starting treatment and at the sixth month of the treatment period). There was an increase in zinc and copper concentrations in liver materials at the sixth month of treatment compared to the pre-treatment values (the median zinc value was 48.05g/g before treatment and 74.9g/g at 6months after initial treatment, p=0.035; median copper was 2.82g/g before treatment and 5.31g/g after 6months, p=0.002). General estimations indicated that zinc (p=0.002), iron (p=0.0244), copper (p=0.0003), and aluminum (p=0.0239) values may be effective in HAI (histological activity index) changes. Only iron levels could be at a very low level effective on the changes caused by fibrosis (p=0.0002). Liver tissue zinc and copper levels increased in parallel with the improvement of inflammation in antiviral-treated HBV patients. In addition, the levels of zinc and copper in the liver tissue can be useful markers for liver tissue damage detection.en_US
dc.identifier.doi10.1007/s12011-018-1414-y
dc.identifier.endpage250en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid29926391en_US
dc.identifier.scopus2-s2.0-85048815685en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-018-1414-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11292
dc.identifier.volume188en_US
dc.identifier.wosWOS:000461991600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis Ben_US
dc.subjectTrace Elementsen_US
dc.subjectLiveren_US
dc.titleChanges in Liver Tissue Trace Element Concentrations During Hepatitis B Viral Infection Treatmenten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu