The Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Study

Basit Öğe Kaydı
dc.contributor.authorNazimTurhal, Serdar
dc.contributor.authorDogan, Mutlu
dc.contributor.authorEsendagli, Guldal
dc.contributor.authorArtac, Mehmet
dc.contributor.authorKorkmaz, Levent
dc.contributor.authorCoskun, Hasan Senol
dc.contributor.authorGoker, Erdem
dc.date.accessioned2024-02-23T13:59:46Z
dc.date.available2024-02-23T13:59:46Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPurpose Plexin C1 is a transmembrane receptor and plexin C1 overexpression might have role in carcinogenesis. Hepatocellular carcinoma (HCC) has poor prognosis because of its aggressive behavior and limited treatment options, especially in advanced stage. We recently documented that Plexin C1 was overexpressed in HCC. We aimed to evaluate the prognostic significance of Plexin C1 overexpression in HCC in the present study. Methods Plexin C1 overexpression was evaluated immunohistochemically on paraffin-embedded blocks of the HCC patients. Plexin C1 immunohistochemical staining was scored. Plexin C1 overexpression staining intensity and prevalence were used for plexin scale staining evaluation and plexin scores were estimated according this staining scale. Plexin C1 score and its association with survival and clinicopathological features was assessed. Results Sixty-seven HCC patients with adequate tissue for pathological evaluation were included. Median age was 63 years with male predominance (male to female ratio was 4.75 (n 57/12). Well-differentiated HCC (53.7%) patients had higher plexin C1 overexpression (p < 0.05). Median OS was 22.1 months. Patients with lower plexin C1 score (< 12) had shorter OS (17.5 vs 30.1 months, p = 0.036). Neutrophil count, GGT, and PNR (platelet/neutrophil ratio) had prognostic significance (p = 0.047, p = 0.018, and p = 0.045). Conclusion Plexin C1 overexpression is inversely correlated with grade in HCC. The patients with lower rate of Plexin C1 overexpression have worse survival outcome. It might be a prognostic factor in HCC.en_US
dc.identifier.doi10.1007/s12029-021-00602-4
dc.identifier.endpage362en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue2en_US
dc.identifier.pmid33656690en_US
dc.identifier.scopus2-s2.0-85131347050en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00602-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11316
dc.identifier.volume53en_US
dc.identifier.wosWOS:000625053000002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectHccen_US
dc.subjectPlexinen_US
dc.titleThe Relationship Between Plexin C1 Overexpression and Survival in Hepatocellular Carcinoma: a Turkish Oncology Group (TOG) Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu