IN VITRO CYTOTOXICITY, ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF VARIOUS EXTRACTS FROM SCHIZOPHYLLUM COMMUNE FR.

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dc.contributor.authorEmsen, Bugrahan
dc.contributor.authorKocabas, Aytac
dc.contributor.authorKaya, Abdullah
dc.contributor.authorCinar, Seval
dc.contributor.authorAasim, Muhammad
dc.contributor.authorSadi, Gokhan
dc.date.accessioned2024-02-23T14:49:00Z
dc.date.available2024-02-23T14:49:00Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractMushrooms have become attractive materials as a source of physiologically valuable bioactive compounds recently. This study was designed to investigate antioxidant, antibacterial and cytotoxic properties of Schizophyllum commune Fr. which is highly distributed worldwide. Five different extracts of S. commune were obtained with different solvent systems. Their antioxidant potentials were determined by measuring bioactive components (beta-carotene, flavonoids, lycopene and total phenols) in conjunction with radical scavenging and metal chelating activities as well as its reducing powers. Antibacterial activities of aqueous and methanol extract were observed on Bacillus subtilis (Ehrenberg) Cohn and Agrobacterium tumefaciens Smith & Townsend. In vitro cytotoxic effects of the extracts against liver hepatocellular carcinoma (HepG2) cell lines after 48 and 72 h incubation were tested. It was found that acetone extract of S. commune had maximum amount of beta-carotene (22.69 mu g/mg), phenolic (27.66 mu g/mg) and lycopene (8.73 mu g/mg) content and n-hexane extract had maximum amount of flavonoid (3.48 mu g/mg). According to IC50 values, the chloroform extract of S. commune showed the highest DPPH capturing (7.652 mg/ml) and metal chelating (6.590 mg/ml) activities. Furthermore, acetone and n-hexane extracts exerted substantial in vitro cytotoxic effects against liver hepatocellular carcinoma (HepG2) cell lines after 72 h incubation with IC50 value of 0.825 and 0.316 mg/ml respectively. Results of this study showed that different extracts of investigated mushroom have considerable cytotoxic and antioxidant properties and may be utilized as a promising source of therapeutics.en_US
dc.description.sponsorshipKaramanoglu Mehmetbey University [37-M-12]en_US
dc.description.sponsorshipThe authors wish to acknowledge the financial support of Karamanoglu Mehmetbey University through the Scientific Research Project (37-M-12).en_US
dc.identifier.endpage1153en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue1Aen_US
dc.identifier.startpage1144en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17942
dc.identifier.volume26en_US
dc.identifier.wosWOS:000395724300073en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMacrofungien_US
dc.subjectSchizophyllum Communeen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAntibacterial Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectHepg2en_US
dc.titleIN VITRO CYTOTOXICITY, ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF VARIOUS EXTRACTS FROM SCHIZOPHYLLUM COMMUNE FR.en_US
dc.typeArticleen_US

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