Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer's Disease

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dc.contributor.authorAltunkaya, Sabri
dc.contributor.authorHuang, Sheng-Min
dc.contributor.authorHsu, Yen-Hsuan
dc.contributor.authorYang, Jir-Jei
dc.contributor.authorLin, Chien-Yuan
dc.contributor.authorKuo, Li-Wei
dc.contributor.authorTu, Min-Chien
dc.date.accessioned2024-02-23T14:34:58Z
dc.date.available2024-02-23T14:34:58Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractFew studies have investigated differences in functional connectivity (FC) between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD), especially in relation to apathy. Therefore, the aim of this study was to compare apathy-related FC changes among patients with SIVD, AD, and cognitively normal subjects. The SIVD group had the highest level of apathy as measured using the Apathy Evaluation Scale-clinician version (AES). Dementia staging, volume of white matter hyperintensities (WMH), and the Beck Depression Inventory were the most significant clinical predictors for apathy. Group-wise comparisons revealed that the SIVD patients had the worst level of Initiation by factor analysis of the AES. FCs from four resting state networks (RSNs) were compared, and the connectograms at the level of intra- and inter-RSNs revealed dissociable FC changes, shared FC in the dorsal attention network, and distinct FC in the salient network across SIVD and AD. Neuronal correlates for Initiation deficits that underlie apathy were explored through a regional-specific approach, which showed that the right inferior frontal gyrus, left middle frontal gyrus, and left anterior insula were the critical hubs. These findings broaden the disconnection theory by considering the effect of FC interactions across multiple RSNs on apathy formation.en_US
dc.identifier.doi10.3389/fnagi.2021.717037
dc.identifier.issn1663-4365
dc.identifier.pmid35185511en_US
dc.identifier.scopus2-s2.0-85124958542en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fnagi.2021.717037
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15836
dc.identifier.volume13en_US
dc.identifier.wosWOS:000759818400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Aging Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional Magnetic Resonance Imagingen_US
dc.subjectResting-State Functional Connectivityen_US
dc.subjectDisconnection Syndromeen_US
dc.subjectApathyen_US
dc.subjectSubcortical Ischemic Vascular Diseaseen_US
dc.subjectAlzheirmer's Diseaseen_US
dc.titleDissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer's Diseaseen_US
dc.typeArticleen_US

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