The Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosis

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dc.contributor.authorEren, Fettah
dc.contributor.authorDemir, Aysegul
dc.contributor.authorEren, Gullu
dc.date.accessioned2024-02-23T14:38:08Z
dc.date.available2024-02-23T14:38:08Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIntroduction: The platelet/lymphocyte ratio (PLR) has been studied frequently to determine the prognosis of cardiovascular diseases, chronic inflammatory diseases, and malignancies. Particularly, the PLR is an indicator of systemic inflammation and atherosclerosis. In this study, we aimed to evaluate the value of the PLR and its relationship with mortality, cerebral hemorrhagic transformation, and short-term prognosis in patients with stroke treated with intravenous thrombolysis. Methods: Two hundred fifty stroke patients treated with intravenous thrombolysis were included in the study. Initial symptoms, comorbidities, and localization of cerebral ischemia were recorded. Disability was scored on the National Institutes of Health (NIH) stroke scale. At the 24Th and 72nd hours after treatment, hemorrhagic transformation was evaluated by brain computed tomography. The in-hospital mortality rate was calculated. Patients were divided into groups according to the difference in the NIH stroke scale (between admission and discharge). Serum platelet and lymphocyte levels and PLR values were determined. Results: There were 128 (51.2%) female and 122 (48.8%) male patients included in the study. Their mean age was 71.88 +/- 12.36 years. The lymphocyte count was low and the PLR was high in patients with a high level of initial disability (p<0.01). The lymphocyte count was higher in patients with clinical improvement (p=0.023). The lymphocyte count was lower and the PLR was higher in patients who died (p<0.01). The platelet level was lower in patients with hemorrhagic transformation (p=0.024). The lymphocyte level and PLR were similar in the hemorrhagic transformation groups (p=0.156, p=0.675). Conclusion: In this study, it was determined that mortality is related to the PLR, and hemorrhagic transformation is related to platelet levels in patients with ischemic stroke treated with intravenous thrombolysis.en_US
dc.identifier.doi10.4274/imj.galenos.2021.89972
dc.identifier.endpage167en_US
dc.identifier.issn2619-9793
dc.identifier.issn2148-094X
dc.identifier.issue2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.4274/imj.galenos.2021.89972
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16380
dc.identifier.volume22en_US
dc.identifier.wosWOS:000642641800015en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofIstanbul Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemic Strokeen_US
dc.subjectIntravenous Thrombolysisen_US
dc.subjectPlatelet/Lymphocyte Ratioen_US
dc.titleThe Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosisen_US
dc.typeArticleen_US

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