Acute long-distance trail running increases serum IL-6, IL-15, and Hsp72 levels

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dc.contributor.authorYargic, Melda Pelin
dc.contributor.authorTorgutalp, Seyma
dc.contributor.authorAkin, Senay
dc.contributor.authorBabayeva, Naila
dc.contributor.authorTorgutalp, Murat
dc.contributor.authorDemirel, Haydar Ali
dc.date.accessioned2024-02-23T14:26:13Z
dc.date.available2024-02-23T14:26:13Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractInterleukin-6 (IL-6), IL-15, and heat shock protein 72 (Hsp72) are molecules that have significant metabolic effects on glucose and fat metabolism and a cell's stress response. The aim of this study is to determine serum levels of these molecules in runners after a long-distance trail run. Serum IL-15 levels after such endurance events have not been investigated yet. Blood samples were collected from 37 athletes (11 female, 26 male) before and after a 35-km trail run, with a total climb of 940 m. Serum was obtained from the samples, and IL-6, IL-15, and Hsp72 levels were measured from using the sandwich ELISA method. The athletes completed the race in 308.3 +/- 37.4 min on average. After the race, the mean serum IL-6, IL-15, and Hsp72 concentrations increased 13.2-fold, 2.22-fold, and 1.6-fold, respectively (p < 0.001, p < 0.001, and p = 0.039, respectively). This is the first study to demonstrate the increase in serum IL-15 levels following an acute endurance exercise. In addition to IL-15, we report that IL-6 and soluble Hsp72 levels also increased significantly following a 35-km trail run. Since these molecules are involved in regulating glucose and fat metabolism, significant increases of IL-6, IL-15, and soluble Hsp72 may have health benefits that may be associated with long-distance trail runs, which are becoming more popular worldwide.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination Unit [2017-13130]en_US
dc.description.sponsorshipThis study was funded by Hacettepe University Scientific Research Projects Coordination Unit (Grant Number 2017-13130). We thank the Cappadocia Ultra-Trail organisers and the runners who participated in our study.en_US
dc.identifier.doi10.1139/apnm-2018-0520
dc.identifier.endpage631en_US
dc.identifier.issn1715-5312
dc.identifier.issn1715-5320
dc.identifier.issue6en_US
dc.identifier.pmid30365907en_US
dc.identifier.scopus2-s2.0-85066634349en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.1139/apnm-2018-0520
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14113
dc.identifier.volume44en_US
dc.identifier.wosWOS:000469928100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Science Publishing, Nrc Research Pressen_US
dc.relation.ispartofApplied Physiology Nutrition And Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRunningen_US
dc.subjectEndurance Trainingen_US
dc.subjectExercise Metabolismen_US
dc.subjectExercise Endocrinologyen_US
dc.subjectCytokinesen_US
dc.subjectStressen_US
dc.titleAcute long-distance trail running increases serum IL-6, IL-15, and Hsp72 levelsen_US
dc.typeArticleen_US

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