Is Neutrophil/Lymphocyte Ratio Predict to Short-term Mortality in Acute Cerebral Infarct Independently from Infarct Volume?

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dc.contributor.authorTokgoz, Serhat
dc.contributor.authorKeskin, Suat
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorSeyithanoglu, Abdullah
dc.contributor.authorOgmegul, Aysegul
dc.date.accessioned2024-02-23T14:13:03Z
dc.date.available2024-02-23T14:13:03Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground: Neutrophil/lymphocyte ratio (NLR) is related with increased mortality in both myocardial infarction and acute ischemic stroke. It remains unclear whether NLR is a simple marker of ischemic infarct volume or an independent marker of stroke mortality. The aim of this study is to investigate the relationship of NLR with infarct volume and short-term mortality in acute ischemic stroke (AIS). Methods: This retrospective study included 151 patients with first AIS that occurred within 24 hours of symptom onset. Patients were screened from the hospital's electronic record system by using International Classification of Diseases code (G 46.8). NLR was calculated as the ratio of neutrophils to lymphocytes. Short-term mortality was defined as 30-day mortality. Results: A total 20 of 151 patients died during follow-up. Both NLR and infarct volume of nonsurvived group were significantly higher than survived group (P < . 05). Infarct volume, NLR, and National Institutes of Health Stroke Scale (NIHSS) were independent predictors of the mortality in Cox regression analysis. The optimal cutoff value for NLR as a predictor for short-term mortality was determined as 4.81. NLR displayed a moderate correlation with both NIHSS and Glasgow Coma Scale (P < . 01). NLR values were significantly higher in the highest infarct volume tertile than both in the lowest volume tertile and midtertile of infarct volume (P = .001). Conclusions: NLR at the time of hospital admission maybe a predictor of short-term mortality independent from infarct volume in AIS patients. NLR should be investigated in future prospective trials investigating AIS.en_US
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2014.04.007
dc.identifier.endpage2168en_US
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue8en_US
dc.identifier.pmid25106834en_US
dc.identifier.scopus2-s2.0-84908162658en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2163en_US
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12283
dc.identifier.volume23en_US
dc.identifier.wosWOS:000341484900037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Stroke & Cerebrovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectAcuteen_US
dc.subjectIschemicen_US
dc.subjectStrokeen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectDiffusion Imagingen_US
dc.titleIs Neutrophil/Lymphocyte Ratio Predict to Short-term Mortality in Acute Cerebral Infarct Independently from Infarct Volume?en_US
dc.typeArticleen_US

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