Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse

Basit Öğe Kaydı
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-02-23T13:59:27Z
dc.date.available2024-02-23T13:59:27Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractDiabetic kidney disease (DKD) can occur in approximately 30-40% of both type 1 and type 2 diabetic patients. The well-established features of DKD include increased serum glucose levels along with chronic low-grade inflammation, OxS, increased advanced glycation end products, sorbitol accumulation, increased hexosamine, and protein kinase C pathway activation. On the other hand, accumulating evidence suggests that novel pathways including apoptosis and autophagy might also play important roles in the pathogenesis and progression of DKD. In this review, the integrated mechanisms of inflammation, oxidative stress, apoptosis, and autophagy are discussed in the pathogenesis as well as progression of DM and DKD.en_US
dc.identifier.doi10.1007/s11255-016-1488-4
dc.identifier.endpage844en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue5en_US
dc.identifier.pmid28035619en_US
dc.identifier.scopus2-s2.0-85007427025en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage837en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-016-1488-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11203
dc.identifier.volume49en_US
dc.identifier.wosWOS:000400031800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectOxidative Stressen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectDiabetesen_US
dc.titleInflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypseen_US
dc.typeReview Articleen_US

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