Investigation of bone biomechanics in rats with traumatic kidney injury

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dc.contributor.authorNalbant, Asrin
dc.contributor.authorSaygin, Duygu Akin
dc.contributor.authorAydin, Arif
dc.contributor.authorAydin Kabakci, Anil Didem
dc.date.accessioned2024-02-23T14:37:49Z
dc.date.available2024-02-23T14:37:49Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: Mineral metabolism disorders are common in chronic kidney disease (CKD) and increase the risk of fractures. It has been confirmed by animal models that these changes in bone also cause negative results in the mechanical properties of bone. Although there are many available methods for diagnosing metabolic bone disorders and estimating fracture risk, it has been suggested that biomechanical tests that provide information about bone's structural and material properties are most appropriate, particularly in small rodents with CKD. Therefore, this study aimed to investigate the effects of trauma-induced kidney damage on bone biomechanical properties. Materials and Methods: In this study, we used 16 adult Wistar Albino rats, 200-300 g, 4-5 months old. The animals were examined under two groups: kidney control (n = 9) and healty kidney control group and kidney damage group (n = 7). In the control group, the rats were fixed by laparotomy, and the kidneys were closed without suturing. However, the kidney damage group was approached by suturing. Results: When the bone biomechanical properties of the control and kidney-damaged groups were compared, a statistically significant difference was found between the displacement at maximum load, duration, and young's modulus groups (P < 0.005). Conclusion: The study showed that the bone biomechanical properties of rats with trauma-induced kidney damage changed, and there was an increased fracture risk.en_US
dc.identifier.doi10.4103/jasi.jasi_164_22
dc.identifier.endpage157en_US
dc.identifier.issn0003-2778
dc.identifier.issn2352-3050
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85165977303en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.4103/jasi.jasi_164_22
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16248
dc.identifier.volume72en_US
dc.identifier.wosWOS:001046536100012en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of The Anatomical Society Of Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBoneen_US
dc.subjectBone Fractureen_US
dc.subjectChronic Kidney Injuryen_US
dc.subjectThree Point Bendingen_US
dc.titleInvestigation of bone biomechanics in rats with traumatic kidney injuryen_US
dc.typeArticleen_US

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