Evaluation of Hemodialysis Adequacy: Correlation between Kt/Vurea and Other Methods

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dc.contributor.authorBaloglu, Ismail
dc.contributor.authorSelcuk, N. Yilmaz
dc.contributor.authorEvran, Hatice
dc.contributor.authorTonbul, Halil Zeki
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-02-23T14:41:19Z
dc.date.available2024-02-23T14:41:19Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: Uremic toxins must be adequately cleared to reduce mortality and morbidity in chronic hemodialysis patients. The second-generation Daugirdas formula (D) is recommended for measurement of hemodialysis adequacy according to the guidelines specified by Kidney Disease Outcomes Quality Initiative (KDOQI) in guidelines. We aimed to compare the Kt/V ratio obtained by D (D Kt/V) to the urea reduction ratio (URR) and the Online Clearance Monitor (OCM (R)). Materials and Methods: Our research is across-sectional study on 48 patients who are on maintenance hemodialysis (HD). A total of 1990 HD sessions were performed 3 times a week for 4 hours each day for 3 months. Ionic dialysate was measured by OCM module of the Fresenius 4008 C machine. In the same HD session, URR and Kt/V ratio were calculated using a single-pool Daugirdas formula. Results: This study included 48 (Male: 24, Female: 24) adult chronic HD patients. Mean age of the patients was 54.5 +/- 18.1 years (16-81 years). Mean Kt/V value was found be higher when calculated using D formula (1.54 +/- 0.36) than what was measured by ionic dialysate (1.37 +/- 0.32) (p<0.0001). Comparison between D Kt/V and URR showed a statistically relevant significance (p<0.0001, r=0.92). Mean ultrafiltration (UF) was 1521 +/- 1054 milliliters per session. When D Kt/V was calculated without UF, the mean Kt/V value measured by ionic dialysate was not different from D Kt/V without considering UF (1.43 +/- 0.32) (p=0.101). In spite of the fact that URR was positively correlated with two formulas, the relationship between D Kt/V and URR was statistically more significant. Conclusion: In our study, Kt/V calculated with D formula was higher than Kt/V measured by OCM. If the Daugirdas formula was calculated without considering UF, the Kt/V found by both methods was similar. Even though the URR correlated with two formulas, the relationship between D Kt/V and URR was statistically more significant. OMC is a practical tool that can help us to assess hemodialysis adequacy.en_US
dc.identifier.doi10.5152/turkjnpehrol.2019.3426
dc.identifier.endpage196en_US
dc.identifier.issn2667-4440
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85088152105en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.5152/turkjnpehrol.2019.3426
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16800
dc.identifier.volume28en_US
dc.identifier.wosWOS:000477574800006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Journal Of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemodialysisen_US
dc.subjectKt/Ven_US
dc.subjectOnline Clearance Monitoren_US
dc.titleEvaluation of Hemodialysis Adequacy: Correlation between Kt/Vurea and Other Methodsen_US
dc.typeArticleen_US

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