The Relationship between Pre-operative Anti-thyroglobulin Antibody Level and Lymph Node Metastasis and Recurrence in Differentiated Thyroid Cancer

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dc.contributor.authorKaynak, Hulya
dc.contributor.authorKocabas, Muhammet
dc.contributor.authorCan, Mustafa
dc.contributor.authorCordan, Ilker
dc.contributor.authorKarakose, Melia
dc.contributor.authorKarakurt, Feridun
dc.contributor.authorKulaksizoglu, Mustafa
dc.date.accessioned2024-02-23T14:41:38Z
dc.date.available2024-02-23T14:41:38Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE We aimed to investigate the relationship between positivity and level of pre-operative anti-thyroglobulin antibody (TgAb) and stage, recurrence, and metastasis in differentiated thyroid cancer (DTC). METHODS Three hundred and thirty-one patients who underwent total thyroidectomy and whose TgAb was measured in the pre-operative and post-operative period were included in the study. The laboratory and clinicopathological data of the patients were recorded from patient files. RESULTS Of the 331 patients enrolled, 253 (76.4%) were female and 78 (23.6) were male, and the mean age was 46.7 +/- 15.4. The final histopathology results were DTC in 126 (38.1%) patients and benign in 205 (61.9%) patients. TgAb was positive in 26 (20.6%) of 126 patients in the DTC group, while it was positive in 29 (14.1%) of 205 patients in the benign group. In patients with DTC, having lymph node metastasis, recurrence, and receiving radioactive iodine (RAI) ablation were found to be associated with higher pre-operative TgAb levels (p=0.023, p=0.032 and p=0.022, respectively). The TSH level at the time of diagnosis was significantly higher in the DTC group compared to the benign group (p<0.001). CONCLUSION In our study, pre-operative TgAb levels were found to be significantly higher in DTC patients with lymph node metastasis or recurrence. We found that pre-operative TgAb level significantly correlated with recurrence and lymph node metastasis.en_US
dc.identifier.doi10.5505/tjo.2022.3615
dc.identifier.endpage35en_US
dc.identifier.issn1300-7467
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85149532191en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2022.3615
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16940
dc.identifier.volume38en_US
dc.identifier.wosWOS:000903519900001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Thyroglobulin Antibodyen_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectLymph Node Metastasisen_US
dc.subjectRecurrenceen_US
dc.titleThe Relationship between Pre-operative Anti-thyroglobulin Antibody Level and Lymph Node Metastasis and Recurrence in Differentiated Thyroid Canceren_US
dc.typeArticleen_US

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