Associations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes An Individual Participant Data Meta-analysis

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dc.contributor.authorVlenterie, Richelle
dc.contributor.authorvan Gelder, Marleen M. H. J.
dc.contributor.authorAnderson, H. Ross
dc.contributor.authorAndersson, Liselott
dc.contributor.authorBroekman, Birit F. P.
dc.contributor.authorDubnov-Raz, Gal
dc.contributor.authorEl Marroun, Hanan
dc.date.accessioned2024-02-23T14:21:05Z
dc.date.available2024-02-23T14:21:05Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: To evaluate the associations of depressive symptoms and antidepressant use during pregnancy with the risks of preterm birth, low birth weight, small for gestational age (SGA), and low Apgar scores. DATA SOURCES: MEDLINE, EMBASE, , and PsycINFO up to June 2016. METHODS OF STUDY SELECTION: Data were sought from studies examining associations of depression, depressive symptoms, or use of antidepressants during pregnancy with gestational age, birth weight, SGA, or Apgar scores. Authors shared the raw data of their studies for incorporation into this individual participant data meta-analysis. TABULATION, INTEGRATION, AND RESULTS: We performed one-stage random-effects meta-analyses to estimate odds ratios (ORs) with 95% CIs. The 215 eligible articles resulted in 402,375 women derived from 27 study databases. Increased risks were observed for preterm birth among women with a clinical diagnosis of depression during pregnancy irrespective of antidepressant use (OR 1.6, 95% CI 1.2-2.1) and among women with depression who did not use antidepressants (OR 2.2, 95% CI 1.7-3.0), as well as for low Apgar scores in the former (OR 1.5, 95% CI 1.3-1.7), but not the latter group. Selective serotonin reuptake inhibitor (SSRI) use was associated with preterm birth among women who used antidepressants with or without restriction to women with depressive symptoms or a diagnosis of depression (OR 1.6, 95% CI 1.0-2.5 and OR 1.9, 95% CI 1.2-2.8, respectively), as well as with low Apgar scores among women in the latter group (OR 1.7, 95% CI 1.1-2.8). CONCLUSION: Depressive symptoms or a clinical diagnosis of depression during pregnancy are associated with preterm birth and low Apgar scores, even without exposure to antidepressants. However, SSRIs may be independently associated with preterm birth and low Apgar scores.en_US
dc.description.sponsorshipNetherlands Organisation for Health Research and Development (ZonMw) Programme Rational Pharmacotherapy [836011020]; National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, UK; Dutch Medical Research Council (NWO) [016 VICI.170.200]; Alberta Center for Child, Family and Community Research; Aga Khan University School of Nursing Student Funden_US
dc.description.sponsorshipThis research was supported by the Netherlands Organisation for Health Research and Development (ZonMw) Programme Rational Pharmacotherapy (grant number 836011020). The funder played no role in the design of the study, analysis or interpretation of findings, or drafting the manuscript and did not review or approve the manuscript prior to submission. Janet L. Peacock is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, UK. Henning Tiemeier was supported by the Dutch Medical Research Council (NWO grant 016 VICI.170.200). The work of Shahirose S. Premji and Kiran Shaikh was funded by Alberta Center for Child, Family and Community Research and the Aga Khan University School of Nursing Student Fund.en_US
dc.identifier.doi10.1097/AOG.0000000000004538
dc.identifier.endpage646en_US
dc.identifier.issn0029-7844
dc.identifier.issue4en_US
dc.identifier.pmid34623076en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage633en_US
dc.identifier.urihttps://doi.org/10.1097/AOG.0000000000004538
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13439
dc.identifier.volume138en_US
dc.identifier.wosWOS:000711778000017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofObstetrics And Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAssociations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes An Individual Participant Data Meta-analysisen_US
dc.typeReview Articleen_US

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