Serum Selenium Levels in Euthyroid Nodular Thyroid Diseases

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dc.contributor.authorSakiz, Davut
dc.contributor.authorKaya, Ahmet
dc.contributor.authorKulaksizoglu, Mustafa
dc.date.accessioned2024-02-23T13:59:42Z
dc.date.available2024-02-23T13:59:42Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe thyroid gland is susceptible to nodulation. The mechanism responsible for the growth of only some follicular cells, which results in nodule formation, is not yet clear. Selenium deficiency may be a risk factor in the development of thyroid nodules. The aim of this study was to investigate the relationship between selenium levels in patients with euthyroid nodular thyroid disease. Seventy patients with a solitary euthyroid thyroid nodule, 70 patients with more than one euthyroid nodule, and 60 healthy patients without thyroid nodules were included in the study. Venous serum samples were stored at -80A degrees C and analyzed the same day using spectrometry. The selenium levels of patients with multiple thyroid nodules, solitary nodules, and patients without nodules were 57.3 +/- 14.8 mu g/L; 58.8 +/- 15.1 mu g/L; and 57.6 +/- 13.3 mu g/L, respectively. The mean serum selenium level of all patients included in the study was 57.9 +/- 14.4 mu g/L. Although serum selenium levels were slightly higher in men, a statistically significant difference was not observed. In our study, a significant relationship between serum selenium levels and nodular thyroid disease was not seen. Our study was undertaken in an iodine sufficient region. Mean serum selenium levels were lower compared with many other studies, which may be associated with the low selenium content of the soil. Nodular thyroid disease shows multifactorial features. When our study is considered together with previous studies, serum selenium levels may considered to be effective on structural thyroid diseases if combined with additional factors such as severe iodine deficiency. Further studies are required to assess the role of selenium in thyroid nodule formation.en_US
dc.description.sponsorshipCoordination Unit of Scientific Projects of Necmettin Erbakan University [131518017]en_US
dc.description.sponsorshipThis study was funded by Coordination Unit of Scientific Projects of Necmettin Erbakan University (Grant number 131518017).en_US
dc.identifier.doi10.1007/s12011-016-0688-1
dc.identifier.endpage26en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid27052308en_US
dc.identifier.scopus2-s2.0-84962704074en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-016-0688-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11290
dc.identifier.volume174en_US
dc.identifier.wosWOS:000385132300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleSerum Selenium Levels in Euthyroid Nodular Thyroid Diseasesen_US
dc.typeArticleen_US

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