Prolonged pulmonary pulse transit time is associated with symptoms in patients with significant mitral stenosis and sinus rhythm

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dc.contributor.authorGurbuz, Ahmet S.
dc.contributor.authorOzturk, Semi
dc.contributor.authorAlsancak, Yakup
dc.contributor.authorSakli, Beyza
dc.contributor.authorDuzenli, Mehmet A.
dc.date.accessioned2024-02-23T12:58:15Z
dc.date.available2024-02-23T12:58:15Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Pulmonary pulse transit time (pPTT) is a novel noninvasive echocardiographic measure to assess pulmonary arterial hemodynamics. It has been shown to be shorter in precapillary pulmonary hypertension (PHT). Mitral stenosis (MS) is one of the causes of postcapillary PHT. We aimed to investigate pPTT in patients with MS and its relationship with symptoms. Methods: We included 51 patients with MS (25 were asymptomatic, NYHA I, and 26 were symptomatic, NHYA II or III), and 50 controls, and evaluated their demographic characteristics and echocardiographic variables, including pPTT. Results: Baseline characteristics, including age, sex, body mass index, and cardiovascular risk factors, were similar between the MS and the control group. The pPTT was longer in the MS group than in the control group (0.21 +/- 0.08 vs 0.15 +/- 0.05, P<.001). Patients with symptomatic MS had longer pPTT than asymptomatic patients (P=.005). The pPTT was positively correlated with left atrial volume index and systolic pulmonary artery pressure, and negatively with tricuspid annular plane systolic excursion (r=.432; P<.001, r=.319; P=.001, r=-.293; and P=.003, respectively). Conclusion: The measurement of pPTT appears clinically relevant in patients with PHT. Further studies evaluating whether it is useful in distinguishing precapillary from postcapillary PHT are required.en_US
dc.identifier.doi10.1002/jcu.22758
dc.identifier.endpage44en_US
dc.identifier.issn0091-2751
dc.identifier.issn1097-0096
dc.identifier.issue1en_US
dc.identifier.pmid31297841en_US
dc.identifier.scopus2-s2.0-85068902336en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1002/jcu.22758
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10615
dc.identifier.volume48en_US
dc.identifier.wosWOS:000474966300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Ultrasounden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial Stiffnessen_US
dc.subjectEchocardiographyen_US
dc.subjectMitral Stenosisen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectPulmonary Pulse Transit Timeen_US
dc.subjectPulmonary Venous Flowen_US
dc.titleProlonged pulmonary pulse transit time is associated with symptoms in patients with significant mitral stenosis and sinus rhythmen_US
dc.typeArticleen_US

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