HPLC-UV analysis of phenolic compounds and biological activities of Padina pavonica and Zanardinia typus marine macroalgae species

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dc.contributor.authorKeskinkaya, Hatice Banu
dc.contributor.authorDeveci, Ebru
dc.contributor.authorAltinok, Bahar Yilmaz
dc.contributor.authorGumus, Numan Emre
dc.contributor.authorAslan, Emine Sukran Okudan
dc.contributor.authorAkkoz, Cengiz
dc.contributor.authorKarakurt, Serdar
dc.date.accessioned2024-02-23T14:41:44Z
dc.date.available2024-02-23T14:41:44Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThe marine macroalgae species are recognized as the food of the future with excellent bioactive properties. This study aimed to investigate phenolic compounds; cytotoxic, antibacterial, and antioxidant activities; total phenolic (TPC) and flavonoid (TFC) contents of the methanol, ethanol, and water extracts of Padina pavonica (PP) and Zanardinia typus (ZT). To the best of our knowledge, this is the first report in which ZT was evaluated in terms of phenolic content, antioxidant, antibacterial, and cytotoxic activities. The HPLC analysis allowed the identification of five phenolic compounds containing rutin (0.31 +/- 0.04 - 3.00 +/- 0.21 ppm) in all extracts and trans- p-coumaric acid (0.15 +/- 0.02 - 3.95 +/- 0.02 ppm) in MPP, EPP, MZT, EZT, WZT as the major compounds. TPC and TFC of the extracts were calculated as 11.78 +/- 0.75 - 76.78 +/- 0.54 mu g GAEs/mg extract and 6.78 +/- 0.17 - 29.50 +/- 2.23 mu g QEs/mg extract, respectively. The highest cytotoxicity was observed in EZT (CC50: 132.3 +/- 22.4 mu g/mL) against MCF-7 and MZT (CC50: 91.4 +/- 20.9 mu g/mL) against MIA PaCa-2. Among the studied extracts, EPP showed the best antibacterial activity against all test pathogens. Also, EPP indicated superior antibacterial activity against Plesiomonas shigelloides (MIC: 1.25 mg/mL) and Staphylococcus aureus (MIC: 1.25 mg/mL). EZT displayed the highest antioxidant activity in DPPH center dot (IC50: 49.03 +/- 0.28 mu g/mL), CUPRAC (A0.50: 15.20 +/- 0.14 mu g/mL), and ABTS center dot+ (IC50: 18.86 +/- 0.74 mu g/mL) assays. The results approved that P. pavonica and Z. typus marine macroalgae species could be valued as natural sources of bioactive agents for food and pharmacology applications.en_US
dc.description.sponsorshipBAP (Coordination of Scientific Researching Projects) Foundation of Selcuk University [SUBAP-20111001]en_US
dc.description.sponsorshipThis study is a part of Hatice Banu KESKINKAYA's doctoral thesis. The authors would like to thank the BAP (Coordination of Scientific Researching Projects) Foundation of Selcuk University for financial support under project SUBAP-20111001.en_US
dc.identifier.doi10.55730/1300-008X.2761
dc.identifier.issn1300-008X
dc.identifier.issn1303-6106
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85163106709en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.55730/1300-008X.2761
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16968
dc.identifier.volume47en_US
dc.identifier.wosWOS:001000545200005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPadina Pavonicaen_US
dc.subjectZanardinia Typusen_US
dc.subjectPhenolic Compoundsen_US
dc.subjectCytotoxic Activityen_US
dc.subjectAntibacterial Activityen_US
dc.subjectAntioxidant Activityen_US
dc.titleHPLC-UV analysis of phenolic compounds and biological activities of Padina pavonica and Zanardinia typus marine macroalgae speciesen_US
dc.typeArticleen_US

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