Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats

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dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorSahin, Zafer
dc.contributor.authorKuzu, Muslum
dc.contributor.authorSaglam, Yavuz Selim
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorUckun, Mirac
dc.contributor.authorYologlu, Ertan
dc.date.accessioned2024-02-23T14:20:34Z
dc.date.available2024-02-23T14:20:34Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIn this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol+lead acetate groups. 8-OhDG immunoreactivity, mononuclear cell infiltrations and hepatic lead concentration were lower in the geraniol+lead acetate group than the lead acetate group. Serum aspartate aminotransferase and alanine aminotransferase activities increased in the Pb acetate group. In conclusion, lead acetate causes oxidative and toxic damage in the liver and this effect can reduce with geraniol treatment. However, we first observed that lead acetate, as well as geraniol, can affect liver carboxylesterase activity.en_US
dc.description.sponsorshipAdiyaman University Scientific Research Projects Unit (ADYUBAP) [FEFYL/2015-0005]en_US
dc.description.sponsorshipThis study was supported by Adiyaman University Scientific Research Projects Unit (ADYUBAP, Project no. FEFYL/2015-0005).en_US
dc.identifier.doi10.1080/13813455.2017.1364772
dc.identifier.endpage87en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue1en_US
dc.identifier.pmid28817314en_US
dc.identifier.scopus2-s2.0-85027878314en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2017.1364772
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13216
dc.identifier.volume124en_US
dc.identifier.wosWOS:000425063500011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives Of Physiology And Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeraniolen_US
dc.subjectLead Acetateen_US
dc.subjectOxidative Stressen_US
dc.subjectCarboxylesteraseen_US
dc.subjectLiveren_US
dc.titleRole of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in ratsen_US
dc.typeArticleen_US

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