Cytomegalovirus infection in immunocompetent wheezy infants: the diagnostic value of CMV PCR in bronchoalveolar lavage fluid

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dc.contributor.authorCinel, G.
dc.contributor.authorPekcan, S.
dc.contributor.authorOzcelik, U.
dc.contributor.authorAlp, A.
dc.contributor.authorYalcin, E.
dc.contributor.authorErsoz, D. Dogru
dc.contributor.authorKiper, N.
dc.date.accessioned2024-02-23T14:24:21Z
dc.date.available2024-02-23T14:24:21Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractWhat is known and objective: Cytomegalovirus (CMV) pneumonitis in immunocompetent hosts is uncommon but is being recognized more frequently, particularly when presenting as severe viral pneumonia. The objective of this study was to examine lower respiratory tract CMV infection in immunocompetent wheezy infants, based on polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid, to compare CMV PCR results in BAL and in blood samples and to evaluate the benefits of antiviral ganciclovir therapy in these patients. Methods: Retrospective review of the records of patients referred to our tertiary care hospital between January 2000 and July 2010 who had unexplained persistent wheezing and underwent fibreoptic flexible bronchoscopy (FFB). Results and discussion: Fibreoptic flexible bronchoscopy was applied to 102 infants with persistent wheezing and diffuse interstitial infiltration on radiological investigations; so CMV PCR in BAL fluid was performed. CMV PCR in BAL fluid was positive in 51 patients. Retrospectively, we had access to the files of 25 of these patients. The mean CMV PCR in BAL fluid was 334 840 copies/mL. Only eight patients had CMV PCR positivity in their blood samples (mean: 2026.3 copies/mL). There was not a relationship between BAL and blood CMV PCR values based on Spearman's correlation analysis (r = -0.008). Fourteen patients had severe respiratory symptoms and received ganciclovir therapy. Twelve of them fully recovered. What is new and conclusion: Bronchoalveolar lavage fluid CMV PCR was superior to blood CMV PCR in diagnosing lower respiratory tract infections caused by CMV in immunocompetent infants. Ganciclovir therapy may be effective in selected immunocompetent wheezy infants with CMV PCR positivity in BAL fluid.en_US
dc.identifier.doi10.1111/jcpt.12169
dc.identifier.endpage403en_US
dc.identifier.issn0269-4727
dc.identifier.issn1365-2710
dc.identifier.issue4en_US
dc.identifier.pmid25040449en_US
dc.identifier.scopus2-s2.0-84904088617en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.1111/jcpt.12169
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13924
dc.identifier.volume39en_US
dc.identifier.wosWOS:000339428100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Pharmacy And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibioticsen_US
dc.subjectInfantsen_US
dc.subjectPaediatricsen_US
dc.subjectTreatment Strategiesen_US
dc.titleCytomegalovirus infection in immunocompetent wheezy infants: the diagnostic value of CMV PCR in bronchoalveolar lavage fluiden_US
dc.typeArticleen_US

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