Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model

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dc.contributor.authorYildiz, Hasan
dc.contributor.authorKalipci, Erkan
dc.contributor.authorOztas, Haydar
dc.contributor.authorYildiz, Deniz
dc.date.accessioned2024-02-23T14:37:53Z
dc.date.available2024-02-23T14:37:53Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractAim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal -SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.en_US
dc.identifier.doi10.4103/jcrt.JCRT_1319_16
dc.identifier.endpage236en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue1en_US
dc.identifier.pmid30880783en_US
dc.identifier.scopus2-s2.0-85063200907en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_1319_16
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16251
dc.identifier.volume15en_US
dc.identifier.wosWOS:000461542500038en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectAzaserineen_US
dc.subjectRatsen_US
dc.subjectSulfhydryl Contenten_US
dc.titleEffects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat modelen_US
dc.typeArticleen_US

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