In Vivo confocal Microscopic evaluation of corneal nerve Fibers and Dendritic cells in Patients With Behcet's Disease

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorKayitmazbatir, Emine Tinkir
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorMalik, Rayaz A.
dc.contributor.authorOzkagnici, Ahmet
dc.date.accessioned2024-02-23T14:34:59Z
dc.date.available2024-02-23T14:34:59Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractCentral and peripheral nervous system involvement may occur during the course of Behcet's disease (BD). In vivo corneal confocal microscopy (CCM) can detect corneal small fiber damage and immune cell density. The aim of this study was to assess central corneal sensitivity, corneal subepithelial nerve plexus morphology and dendritic cell (DC) density in patients with BD. Forty-nine consecutive patients with BD and 30 healthy control subjects were included in this cross-sectional study conducted at a tertiary referral university hospital. Central corneal sensitivity was measured using the contact corneal esthesiometer (Cochet-Bonnet; Luneau, France). The laser scanning CCM (Heidelberg, Germany) was used to quantify corneal nerve fiber density (NFD), nerve branch density (NBD), nerve fiber length (NFL), and DC density. There was a significant reduction in NFD (P = 0.001) and NFL (P = 0.031) and an increase in DC density (P = 0.038) in patients with BD compared to healthy controls, whereas corneal sensitivity (P = 0.066) and NBD (P = 0.067) did not differ significantly. There was no difference in corneal sensitivity, corneal nerve parameters, or DC density between BD patients with [n = 18 (36.7%)] and without a previous history of uveitis (P > 0.05 for all). Disease duration [median (IQR), 6.5 (4.0-14.5) years] correlated with corneal sensitivity (rho = -0.463; P = 0.001) and NFD (rho = -0.304; P = 0.034) and corneal sensitivity correlated with NFD (rho = 0.411; P = 0.003) and NFL (rho = 0.295; P = 0.039) in patients with BD. CCM demonstrates corneal sub-basal nerve fiber loss and increased DC density, providing a non-invasive ophthalmic means to identify peripheral neuropathy and inflammation in patients with BD.en_US
dc.identifier.doi10.3389/fneur.2018.00204
dc.identifier.issn1664-2295
dc.identifier.pmid29643833en_US
dc.identifier.scopus2-s2.0-85044656321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fneur.2018.00204
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15838
dc.identifier.volume9en_US
dc.identifier.wosWOS:000428549900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectCorneal Confocal Microscopyen_US
dc.subjectCorneal Nervesen_US
dc.subjectCorneal Sensitivityen_US
dc.subjectDendritic Cellsen_US
dc.titleIn Vivo confocal Microscopic evaluation of corneal nerve Fibers and Dendritic cells in Patients With Behcet's Diseaseen_US
dc.typeArticleen_US

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