Is the ratio of the index to ring finger length, a potential marker for prenatal testosterone-estrogen balance, related to posterior tibial slope?

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dc.contributor.authorYaka, Haluk
dc.contributor.authorOzer, Mustafa
dc.date.accessioned2024-02-23T14:13:05Z
dc.date.available2024-02-23T14:13:05Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground: The 2D:4D ratio, an indicator of prenatal testosterone-estrogen balance, is the index finger (second finger) size's ratio to the ring finger (fourth finger) size. Asymmetric growth in the proximal tibial growth plate is considered to cause the increased posterior tibial slope (PTS) formation. Factors determining the amount of this asymmetry still need clarification. This study aims to evaluate the relationship between the 2D:4D ratio, which indicates the prenatal testosterone-estrogen balance, and the PTS. Method: Meeting the study criteria, 267 patients were included in the study. We measured the medial PTS (MPTS) and lateral PTS (LPTS) on MRI images and the lengths of the second and fourth fingers on both hands of the patients. Additionally, we compared 2D:4D ratios and MPTS and LPTS measurements. Results: We found a significant negative correlation between MPTS and the 2D:4D ratio, as well as between LPTS and the 2D:4D ratio in both hands (MPTS left vs. right hand: P < 0.001, r = -0.627 vs. P < 0.001, r = -0.498) (LPTS left vs. right hand: P < 0.001, r = 0.589 vs. P < 0.001, r = 0.404). Separately among males and females, there was a significant negative correlation between MPTS and the 2D:4D ratio, as well as between LPTS and the 2D:4D ratio in both hands (for males: MPTS left vs. right hand: P < 0.001, r = -0.607 vs. P < 0.001, r = -0.540)(for males: LPTS left vs.right hand: P < 0.001, r = 0.451 vs. P < 0.001, r = 0.406) (for females:MPTS left vs. right hand: P < 0.001, r = -0.638 vs. P < 0.001, r = -0.446) (for females:LPTS left vs.right hand: P < 0.001, r = 0.618 vs. P < 0.001, r = 0.403). Conclusions: The 2D:4D ratio, an indicator of intrauterine testosterone-estrogen balance, is related to PTS. The effect of testosterone on the growth plate of the proximal tibia may be one of the factors determining the PTS value. Level of evidence: III retrospective comparative study. & COPY; 2023 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.knee.2023.07.001
dc.identifier.endpage207en_US
dc.identifier.issn0968-0160
dc.identifier.issn1873-5800
dc.identifier.pmid37459693en_US
dc.identifier.scopus2-s2.0-85165009015en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.1016/j.knee.2023.07.001
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12296
dc.identifier.volume43en_US
dc.identifier.wosWOS:001041640000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofKneeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPosterior Tibial Slopeen_US
dc.subjectTestosteroneen_US
dc.subjectEstrogenen_US
dc.subject2den_US
dc.subject4d Ratioen_US
dc.titleIs the ratio of the index to ring finger length, a potential marker for prenatal testosterone-estrogen balance, related to posterior tibial slope?en_US
dc.typeArticleen_US

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