Epilepsy and Sex Hormones

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dc.contributor.authorGenc, Emine
dc.contributor.authorGenc, Bulent Oguz
dc.date.accessioned2024-02-23T14:31:38Z
dc.date.available2024-02-23T14:31:38Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractThere is a mutual interaction between sex steroid hormones and epilepsy. Although female and male sex hormones and their metabolites access the brain via the blood brain barrier, they can also be synthesized de novo from cholesterol within the glia and neurones (neurosteroids). While estrogens enhance neuronal excitability, progesterone and its metabolites exert anticonvulsant effects. Testosterone, on the other hand, has a less consistent effect on seizure susceptibility, depending on the ratio of its conversion to estrogens. This paper focuses on the effects of neurosteroidal sex hormones on seizure susceptibility. Further study is required to identify the future role of their use in the treatment of epilepsy.en_US
dc.identifier.doi10.14744/epilepsi.2018.42204
dc.identifier.endpage9en_US
dc.identifier.issn1300-7157
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.14744/epilepsi.2018.42204
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15276
dc.identifier.volume24en_US
dc.identifier.wosWOS:000438304900003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofEpilepsien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsyen_US
dc.subjectNeurosteroidsen_US
dc.subjectEstrogenen_US
dc.subjectProgesteroneen_US
dc.subjectSex Hormonesen_US
dc.subjectTestosteroneen_US
dc.titleEpilepsy and Sex Hormonesen_US
dc.typeReview Articleen_US

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