Ten-year outcomes of patients who developed persistent azoospermia following chemotherapy associated with different oncological diagnoses: A retrospective cohort study from a different perspective

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dc.contributor.authorSalvarci, Ahmet
dc.contributor.authorGurbuz, Ali Sami
dc.contributor.authorBalasar, Mehmet
dc.date.accessioned2024-02-23T14:41:44Z
dc.date.available2024-02-23T14:41:44Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: This study evaluated the treatment procedures for chemotherapy (CT)-induced persistent azoospermia and their outcomes from a different perspective. Materials and methods: In 63 patients (mean age: 30.16 +/- 4.91 years) who had undergone CT 11 +/- 5 years earlier, the semen volume, gonadotropins level, FSH level, genetics, micro-testicular sperm extraction (m-TESE) result, sperm DNA fragmentation index (SDFI), semen reactive oxidative stress (ROS) rate, duration of embryonic development, and pregnancy and baby take-home rates were examined. The correlations between the ROS rates and the SDFIs, m-TESE results, sperm motility, pathology scores, time-lapses, and baby take-home rates were evaluated. Results: The semen volumes were 3.5 +/- 1.1/ml. The FSH level following CT was 17.87 +/- 5.80 mIU/ml. A sperm rate of 34.9% was found from the m-TESE result. The mean SDFI and ROS rate were 4 (<15-30>) and 1.29 +/- 0.51, respectively. The time-lapse was calculated as 5h. Pregnancy and live birth were achieved at 20.63% and 12.7%, respectively. In the patients with a low ROS (<= 1.42) and SDFI (<= 15), the m-TESE success rate was high, the FSH value was low, the pathological score and fertilization rate were elevated, the embryonic cleavage period was normal, and the pregnancy and baby take-home rates were high. Conclusion: The sperms may be detected using m-TESE in patients who develop persistent azoospermia associated with CT due to different oncological diagnoses. Our study revealed that a low FSH value and normal ejaculatory ROS rates are positive predictive factors of sperm detection before m-TESE. The motility of the sperms detected after m-TESE and normal SDFI rates were found to be positive predictive criteria of high fertilization, good embryonic cleavage, pregnancy, and live birth.en_US
dc.identifier.doi10.55730/1300-0144.5373
dc.identifier.endpage787en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid36326321en_US
dc.identifier.scopus2-s2.0-85134545012en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage778en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5373
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16973
dc.identifier.volume52en_US
dc.identifier.wosWOS:000816957200031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzoospermiaen_US
dc.subjectChemotherapyen_US
dc.subjectM-Teseen_US
dc.subjectSdfien_US
dc.subjectRosen_US
dc.subjectMaleen_US
dc.subjectInfertilityen_US
dc.titleTen-year outcomes of patients who developed persistent azoospermia following chemotherapy associated with different oncological diagnoses: A retrospective cohort study from a different perspectiveen_US
dc.typeArticleen_US

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