The Effects of Topical Insulin Application on Wound Healing

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dc.contributor.authorKargin, Suleyman
dc.contributor.authorTastekin, Didem
dc.contributor.authorKilic, Kemal
dc.contributor.authorCezik, Azamet
dc.contributor.authorCakir, Murat
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorKokbudak, Naile
dc.date.accessioned2024-02-23T14:29:54Z
dc.date.available2024-02-23T14:29:54Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThe process of wound healing is a dynamic event during which the stages of fibroplasia, angiogenesis, and re-epithelization perfectly take place. The aim of this study is to compare the effects of wound irrigation by normal saline and topical insulin application, which we frequently use in clinical practice, on wound healing. The study covers a total of 20 male rats - 10 for the insulin group and 10 for the control group. The first group received topical insulin application while the second group had irrigation by normal saline. The macroscopic outlook, collagen production, and wound contraction rates in the animals wounds were checked at the end of day 20. The rate of wound closing was found to be higher in the topical insulin group than the NS group at all times. Further, the period of complete wound closing was shorter than the insulin group. Histopathological analysis revealed that the ulceration and inflammation were localized in the subepithelial field in the skin cross-sections of the insulin group and that there was a significant increase in collagen bundles. Thus, we think that insulin can be an alternative to normal saline application specifically in chronic wounds related to diabetes and post-op wound care.en_US
dc.identifier.doi10.15197/ejgm.01418
dc.identifier.endpage306en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84949817570en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.15197/ejgm.01418
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14917
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382751900004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal Of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTopical Insulinen_US
dc.subjectWound Healingen_US
dc.subjectChronic Wounden_US
dc.titleThe Effects of Topical Insulin Application on Wound Healingen_US
dc.typeArticleen_US

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