Heterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayers

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dc.contributor.authorVakurov, Alex
dc.contributor.authorDrummond-Brydson, Rik
dc.contributor.authorWilliam, Nicola
dc.contributor.authorSanver, Didem
dc.contributor.authorBastus, Neus
dc.contributor.authorMoriones, Oscar H.
dc.contributor.authorPuntes, V.
dc.date.accessioned2024-02-23T14:16:35Z
dc.date.available2024-02-23T14:16:35Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe interaction of amorphous silica nanoparticles with phospholipid monolayers and bilayers has received a great deal of interest in recent years and is of importance for assessing potential cellular toxicity of such species, whether natural or synthesized for the purpose of nanomedical drug delivery and other applications. This present communication studies the rate of silica nanoparticle adsorption on to phospholipid monolayers in order to extract a heterogeneous rate constant from the data. This rate constant relates to the initial rate of growth of an adsorbed layer of nanoparticles as SiO2 on a unit area of the monolayer surface from unit concentration in dispersion. Experiments were carried out using the system of dioleoyl phosphatidylcholine (DOPC) monolayers deposited on Pt/Hg electrodes in a flow cell. Additional studies were carried out on the interaction of soluble silica with these layers. Results show that the rate constant is effectively constant with respect to silica nanoparticle size. This is interpreted as indicating that the interaction of hydrated SiO2 molecular species with phospholipid polar groups is the molecular initiating event (MIE) defined as the initial interaction of the silica particle surface with the phospholipid layer surface promoting the adsorption of silica nanoparticles on DOPC. The conclusion is consistent with the observed significant interaction of soluble SiO2 with the DOPC layer and the established properties of the silica-water interface.en_US
dc.description.sponsorshipEU [229244, 685817, 862296]en_US
dc.description.sponsorshipWe acknowledge EU for supporting ENNSATOX GA No. 229244, HISENTS GA No. 685817, and SABYDOMA GA No 862296.en_US
dc.identifier.doi10.1021/acs.langmuir.1c03155
dc.identifier.endpage5380en_US
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.issue18en_US
dc.identifier.pmid35471829en_US
dc.identifier.scopus2-s2.0-85129219830en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5372en_US
dc.identifier.urihttps://doi.org/10.1021/acs.langmuir.1c03155
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12725
dc.identifier.volume38en_US
dc.identifier.wosWOS:000813288200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofLangmuiren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleHeterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayersen_US
dc.typeArticleen_US

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