Predictive and prognostic value of preoperative complete blood count in prostate cancer

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dc.contributor.authorKokenek-Unal, Tuba Dilay
dc.contributor.authorFindik, Siddika
dc.date.accessioned2024-02-23T14:40:46Z
dc.date.available2024-02-23T14:40:46Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractAim: The predictive and prognostic value of complete blood count (CBC) In different types of cancer has been frequently demonstrated in recent years. Prostate cancer is the second most common cancer in men worldwide and is one of the most leading causes of death. In our study, we sought to find out whether CBC parameters could distinguish patients with prostate cancer from patients with benign prostatic hyperplasia. Material and Method: Laboratory findings and histopathological findings of totally 93 patients were retrospectively re-evaluated. The absolute neutrophil count (ANC), the absolute lymphocyte count (ALC), platelet count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) values were noted. In patients with prostate cancer, pathological parameters such as prostate weight, tumor percentage. Gleason score perineural invasion, seminal vesicle involvement, apical and radial margin involvement, extra-prostatic extension were determined. Results: In our study, we found that ANC, NLR, PLR, and MPV were significantly different between patients with benign prostatic hyperplasia and with prostate cancer (p < 0.05). We found that ANC and MPV were much more successful in discriminating these patients (p < 0.001). We have shown that ANC has higher specificity and MPV value has higher sensitivity. However, we didn't find any correlation between blood parameters and pathological parameters in patients with prostate cancer. Discussion: Our study has shown that ANC, NLR, PLR, and MPV have the ability to discriminate malignant lesions from benign lesions. Although no correlation with pathologic parameters can be determined, we think that CBC might be evaluated as an auxiliary tool for prostate cancer diagnosis.en_US
dc.identifier.doi10.4328/JCAM.5947
dc.identifier.endpage547en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue6en_US
dc.identifier.startpage543en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.5947
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16573
dc.identifier.volume9en_US
dc.identifier.wosWOS:000445434700017en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCbcen_US
dc.subjectNlren_US
dc.subjectMpven_US
dc.subjectPlren_US
dc.subjectProstate Canceren_US
dc.titlePredictive and prognostic value of preoperative complete blood count in prostate canceren_US
dc.typeArticleen_US

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