Effects of hydroxychloroquine and its metabolites in patients with connective tissue diseases

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dc.contributor.authorOnmaz, Duygu Eryavuz
dc.contributor.authorTezcan, Dilek
dc.contributor.authorAbusoglu, Sedat
dc.contributor.authorYilmaz, Sema
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorOnmaz, Mustafa
dc.contributor.authorAbusoglu, Gulsum
dc.date.accessioned2024-02-23T13:56:10Z
dc.date.available2024-02-23T13:56:10Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractHydroxychloroquine has attracted attention in the treatment of COVID-19. Many conflicting findings have been reported regarding the efficacy and safety of this drug, which has been used safely in the rheumatological diseases for years. However, these studies lacked measurement methods that allow accurate assessment of hydroxychloroquine and its metabolite levels. The aim of this study was to measure hydroxychloroquine and its metabolite levels in whole blood samples of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren's syndrome (SS) and scleroderma (Scl) by a robust, simple and accurate validated tandem mass spectrometric method, and to investigate the relationship between these levels with drug-related adverse effects and disease activity scores. The validated LC-MS/MS method was applied to measure blood hydroxychloroquine and its metabolite levels of patients with RA, SLE, SS, Scl. Various haematological and biochemical parameters were measured with Beckman-Coulter AU 5800 and Beckman Coulter LH 780 analyzers, respectively. QTc intervals were calculated with Bazett's formula, and the patients were followed up by clinicians in terms of clinical findings and adverse effects. Hydroxychloroquine levels of patients were similar to previous studies. There was a negative correlation between disease activity scores and hydroxychloroquine levels, while the highest correlation was between QTc interval, creatinine and GFR levels with desethylchloroquine. Bidetylchloroquine had the highest correlation with RBC count and liver function tests. Our findings showed that hydroxychloroquine and its metabolite levels were associated with disease activity scores, renal, hepatic function, QTc prolongation, and hematological parameters.en_US
dc.identifier.doi10.1007/s10787-021-00887-8
dc.identifier.endpage1805en_US
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.issue6en_US
dc.identifier.pmid34743268en_US
dc.identifier.scopus2-s2.0-85118590365en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1795en_US
dc.identifier.urihttps://doi.org/10.1007/s10787-021-00887-8
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11108
dc.identifier.volume29en_US
dc.identifier.wosWOS:000715207300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Basel Agen_US
dc.relation.ispartofInflammopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydroxychloroquineen_US
dc.subjectRheumatological Diseasesen_US
dc.subjectCovid-19en_US
dc.subjectAdverse Effectsen_US
dc.subjectQtc Prolongationen_US
dc.titleEffects of hydroxychloroquine and its metabolites in patients with connective tissue diseasesen_US
dc.typeArticleen_US

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