Sedation for Colonoscopy: Comparison of Remifentanil and Alfentanil Combined with Propofol/Midazolam

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dc.contributor.authorAncan, Sule
dc.contributor.authorCicekci, Faruk
dc.contributor.authorHacibeyoglu, Gulcin
dc.contributor.authorSizer, Cigdem
dc.contributor.authorUzun, Sema Tuncer
dc.contributor.authorDertli, Ramazan
dc.contributor.authorKeskin, Muharrem
dc.date.accessioned2024-02-23T14:38:08Z
dc.date.available2024-02-23T14:38:08Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Different drug combinations are used in patients who underwent colonoscopy for safe sedation and early discharge. Remifentanil and alfentanil are short-acting narcotic analgesic agents. A short-acting anxiolytic agent, midazolam has a potent sedative efficiency when combined with narcotic analgesics. In this study, we aimed to compare the effectiveness of the two opioids that have not been previously compared in the literature, combined with propofol/midazolam in patients who underwent colonoscopy. Methods: One hundred eighty-nine patients aged over 18 years who underwent diagnostic and/or therapeutic colonoscopy were included in the study. 1 mg midazolam + 5 mu g kg-1 alfentanil + 1 mg kg-1 propofol were administered in the alfentanil group (group A), while 1 mg midazolam + 0.1 mu g kg-1 min-1 remifentanil + 1 mg kg-1 propofol were administered in the remifentanil group (group R). Hemodynamic data, Modified Steward scale (MSS), Visual Analog scale (VAS), additional propofol doses, total procedure time, awake time, recovery time, and side effects were recorded during the procedure. After the procedure, all patients were transferred to the recovery room, and the Modified Aldrete scale (MAS) values were recorded. Results: There was a statistically significant difference between the groups in terms of total propofol and additional propofol doses (p<0.05), with additional propofol dose being higher in group A compared to group R (p<0.05). Awake time was similar between the groups. Recovery time was longer in group A compared to group R (p<0.05). No significant difference was observed in the side effects between both groups. Conclusion: Although the low dose of midazolam combined with propofol/remifentanil and propofol/alfentanil provided adequate sedation and analgesia, we believe that remifentanil is an ideal choice for daily procedures like colonoscopy because of its advantages resulting from its pharmacological properties.en_US
dc.identifier.doi10.4274/imj.galenos.2019.26566
dc.identifier.endpage518en_US
dc.identifier.issn2619-9793
dc.identifier.issn2148-094X
dc.identifier.issue6en_US
dc.identifier.startpage512en_US
dc.identifier.urihttps://doi.org/10.4274/imj.galenos.2019.26566
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16371
dc.identifier.volume20en_US
dc.identifier.wosWOS:000502778500006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIstanbul Training & Research Hospitalen_US
dc.relation.ispartofIstanbul Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlfentanilen_US
dc.subjectColonoscopyen_US
dc.subjectRemifentanilen_US
dc.subjectSedationen_US
dc.titleSedation for Colonoscopy: Comparison of Remifentanil and Alfentanil Combined with Propofol/Midazolamen_US
dc.typeArticleen_US

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