Patients' concerns regarding biological agents in rheumatology

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dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorOrucoglu, Nurdan
dc.contributor.authorPehlivan, Seda
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorZengin, Orhan
dc.contributor.authorKucuk, Adem
dc.contributor.authorSahin, Ali
dc.date.accessioned2024-02-23T14:24:00Z
dc.date.available2024-02-23T14:24:00Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractObjectiveThe potential side effects of biological agents may increase the anxiety levels of patients and influence not only their desire to use these therapies but also their concordance to treatment. This study aimed to determine the level and prevalence of drug-related concern in patients treated with biological agents and to acquire additional information regarding the related causes. Materials and MethodsA total of 1134 patients who were using biological agents for at least 3months with a diagnosis of rheumatic diseases were enrolled. General anxiety levels were evaluated using the State-Trait Anxiety Inventory (STAI). ResultsThe most common cause for drug-related concerns was the potential side effects of the drugs (59.5%). Among the potential side effects, cancer risk was the most common cause for concern (40.1%), followed by the risk of tuberculosis activation (30.7%). Anxiety levels were higher in patients who experienced side effects than in other patients, and this difference was statistically significant (P<0.05). STAI trait and state scores were moderately correlated with anxiety levels related to the drug (P<0.001). ConclusionAnxiety related to biological agents may significantly affect the patients' anxiety levels. Awareness regarding the patients' concerns and expectations related to the drug is important to ensure drug adherence and concordance to treatment.en_US
dc.identifier.doi10.1111/1756-185X.13319
dc.identifier.endpage1226en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue6en_US
dc.identifier.pmid29879318en_US
dc.identifier.scopus2-s2.0-85048281645en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1219en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13319
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13765
dc.identifier.volume21en_US
dc.identifier.wosWOS:000434417500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Agentsen_US
dc.subjectPatienten_US
dc.subjectPatients' Concernen_US
dc.subjectRheumatologyen_US
dc.titlePatients' concerns regarding biological agents in rheumatologyen_US
dc.typeArticleen_US

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