The Relationship between Serum Oxalic Acid, Central Hemodynamic Parameters and Colonization by Oxalobacter formigenes in Hemodialysis Patients

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dc.contributor.authorGulhan, Baris
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorAydin, Merve
dc.contributor.authorGunay, Murat
dc.contributor.authorCikman, Aytekin
dc.contributor.authorKara, Murat
dc.date.accessioned2024-02-23T14:26:39Z
dc.date.available2024-02-23T14:26:39Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground/Objective: Elevated pulse wave velocity (PWV) and central aortic blood pressures are independent predictors of increased cardiovascular morbidity and mortality in hemodialysis (HD) patients. Oxalic acid is a uremic retention molecule that is extensively studied in the pathogenesis of calcium oxalate stones. Oxalobacter formigenes, a member of the colon microbiota, has important roles in oxalate homeostasis. Data regarding the colonization by and the exact role of Oxalobacter formigenes in the pathogenesis of oxalic acid metabolism in HD patients are scant. Hence, we aimed to determine the relationship between fecal Oxalobacter formigenes colonization, serum oxalic acid and hemodynamic parameters in HD patients with regard to the colo-reno-cardiac axis. Methods: Fifty HD patients were enrolled in this study. PWV and central aortic systolic (cASBP) and diastolic blood pressures (cADBP) were measured with a Mobil-O-Graph (I.E.M. GmbH, Stolberg, Germany). Serum oxalic acid levels were assessed by ELISA, and fecal Oxalobacter formigenes DNA levels were isolated and measured by real-time PCR. Results: Isolation of fecal Oxalobacter formigenes was found in only 2 HD patients. One of them had 113,609 copies/ml, the other one had 1,056 copies/ml. Serum oxalic acid levels were found to be positively correlated with PWV (r = 0.29, p = 0.03), cASBP (r = 0.33, p = 0.001) and cADBP (r = 0.42, p = 0.002) and negatively correlated with LDL (r = -0.30, p = 0.03). In multivariate linear regression analysis, PWV was independently predicted by oxalic acid, glucose and triglyceride. Conclusions: This is the first study that demonstrates the absence of Oxalobacter formigenes as well as a relation between serum oxalic acid and cASBP, cADBP and PWV in HD patients. Replacement of Oxalobacter formigenes with pre- and probiotics might decrease serum oxalic acid levels and improve cardiovascular outcomes in HD patients. (C) (C) 2015 S. Karger AG, Baselen_US
dc.description.sponsorshipScientific Investigation and Project Foundation of Mengucek Gazi Training and Research Hospital of Erzincan Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Investigation and Project Foundation of the Mengucek Gazi Training and Research Hospital of Erzincan University.en_US
dc.identifier.doi10.1159/000381219
dc.identifier.endpage174en_US
dc.identifier.issn1664-3828
dc.identifier.issn1664-5502
dc.identifier.issue3en_US
dc.identifier.pmid26195968en_US
dc.identifier.scopus2-s2.0-84930892899en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.1159/000381219
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14271
dc.identifier.volume5en_US
dc.identifier.wosWOS:000356097900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofCardiorenal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxalobacter Formigenesen_US
dc.subjectOxalic Aciden_US
dc.subjectPulse Wave Velocityen_US
dc.subjectCentral Aortic Blood Pressuresen_US
dc.subjectColo-Reno-Cardiac Axisen_US
dc.titleThe Relationship between Serum Oxalic Acid, Central Hemodynamic Parameters and Colonization by Oxalobacter formigenes in Hemodialysis Patientsen_US
dc.typeArticleen_US

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