Toxic epidermal necrolysis treated with N-acetylcysteine

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dc.contributor.authorYavuz, Haluk
dc.contributor.authorEmiroglu, Melike
dc.date.accessioned2024-02-23T14:24:35Z
dc.date.available2024-02-23T14:24:35Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractAdverse drug reactions are the major cause of morbidity and mortality worldwide. Cutaneous drug reaction is the most common type of adverse reaction. Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous disease, usually attributable to drugs. There is no proven therapy for TEN. The mainstay of therapy is immediate withdrawal of the culprit drug, using disease-modifying agents, and meticulous supportive care. Several disease-modifying agents have been used such as steroid, i.v. human immunoglobulin (IVIg), plasmapheresis. A 10-year-old epileptic girl was admitted with lamotrigine-induced TEN. She was unresponsive to steroid. Her condition deteriorated despite IVIg treatment. She was treated with N-acetylcysteine (NAC). To our knowledge this is the first report of a child with TEN, a potentially lethal disorder, treated with NAC. NAC may be effective for children with TEN.en_US
dc.identifier.doi10.1111/ped.12410
dc.identifier.endpageE54en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue5en_US
dc.identifier.pmid25336009en_US
dc.identifier.scopus2-s2.0-84939233006en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE52en_US
dc.identifier.urihttps://doi.org/10.1111/ped.12410
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14019
dc.identifier.volume56en_US
dc.identifier.wosWOS:000344243200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCutaneous Drug Reactionen_US
dc.subjectIen_US
dc.subjectVen_US
dc.subjectHuman Immunoglobulinen_US
dc.subjectLamotrigineen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectToxic Epidermal Necrolysisen_US
dc.titleToxic epidermal necrolysis treated with N-acetylcysteineen_US
dc.typeArticleen_US

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