Comparison of Oral Sodium Bicarbonate and Solifenacin Treatment in Female Overactive Bladder Patients With Acidic Urine pH

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dc.contributor.authorSonmez, Mehmet Giray
dc.contributor.authorEcer, Gokhan
dc.contributor.authorAtici, Ahmet
dc.contributor.authorOzkent, Mehmet Serkan
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-02-23T14:23:31Z
dc.date.available2024-02-23T14:23:31Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective In this study, we planned to compare the effects of oral sodium bicarbonate (NaHCO3) and anticholinergic (solifenacin) treatments in women with overactive bladder (OAB) and acidic urine pH values (<6). Methods According to the referral order of OAB patients, 8 g/d oral NaHCO3(group 1) or 5 mg/d solifenacin succinate (group 2) was given to the patients. Both treatment regimens were applied one at a time for 12 weeks in total. Laboratory values, bladder diary, Patient Perception of Bladder Condition score, Patient Perception of Intensity of Urgency Scale, Overactive Bladder-Validated 8-Question Awareness Tool, and the King's Health Questionnaire (KHQ) scores before and after treatment were compared. Results A total of 59 patients were evaluated. Thirty-one patients were included in group 1, and 28 patients were included in group 2. No difference was detected in pretreatment and posttreatment laboratory values other than urine pH values in both groups. Whereas there was no difference in pretreatment urine pH values among the 2 groups, posttreatment urine pH values were significantly higher in group 1 compared with group 2 (P= 0.08,P< 0.001, respectively). There was a significant amelioration in the bladder diary parameters, symptom scores, and KHQ values measured after treatment in both groups. However, degree of amelioration in posttreatment outcomes was similar among the groups. Conclusions It was demonstrated that urinary alkalization made with oral NaHCO(3)in female OAB patients with acidic urine pH had a significantly positive effect on symptoms and symptom scores, and these results are similar to the results of solifenacin treatment.en_US
dc.identifier.doi10.1097/SPV.0000000000000642
dc.identifier.endpage653en_US
dc.identifier.issn2151-8378
dc.identifier.issn2154-4212
dc.identifier.issue10en_US
dc.identifier.pmid30335650en_US
dc.identifier.scopus2-s2.0-85092537095en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage649en_US
dc.identifier.urihttps://doi.org/10.1097/SPV.0000000000000642
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13589
dc.identifier.volume26en_US
dc.identifier.wosWOS:000575669200014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofFemale Pelvic Medicine And Reconstructive Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcidic Urine Phen_US
dc.subjectAnticholinergic Drugsen_US
dc.subjectOveractive Bladderen_US
dc.subjectSodium Bicarbonateen_US
dc.subjectUrinary Alkalizationen_US
dc.titleComparison of Oral Sodium Bicarbonate and Solifenacin Treatment in Female Overactive Bladder Patients With Acidic Urine pHen_US
dc.typeArticleen_US

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