Effects of diclofenac sodium and octreotide on treatment of caerulein-induced acute pancreatitis in mice

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dc.contributor.authorCakir, Ozlem Ozer
dc.contributor.authorEsen, Hasan
dc.contributor.authorToker, Aysun
dc.contributor.authorAtaseven, Huseyin
dc.contributor.authorDemir, Ali
dc.contributor.authorPolat, Hakki
dc.date.accessioned2024-02-23T14:48:40Z
dc.date.available2024-02-23T14:48:40Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Research continues to develop novel therapeutic modalities that particularly focus on the pathogenesis of acute pancreatitis. This study aimed to assess the effects of diclofenac sodium and octreotide, alone or in combination, on pancreatic enzymes, pancreatic myeloperoxidase activity, histopathology and apoptosis of pancreas cells, using a model of experimentally induced acute pancreatitis. Objectives: We aimed to demonstrate effects of diclofenac sodium, octreotide and their combined use on pancreatic enzymes, activity of pancreatic myeloperoxidase (MPO) activity, histopathology and apoptosis of pancreas on treatment of caerulin-induced experimental acute pancreatitis. Materials and methods: Caerulin-induced acute pancreatitis model was created using a total of 58 male BALB-C mice of 25 gr in seven groups. Serum amylase, lipase levels and pancreatic myeloperoxidase activity were examined as well as apoptotic values in pancreatic acinar cells through TUNNEL method. Histopathology of pancreas was evaluated for presence of edema, hemorrhage, parenchymal necrosis, fat necrosis, leukocyte infiltration, and fibrosis. Results: In the diclofenac sodium group, apoptotic values in the pancreatic acinar cells were found to be statistically lower than in the acute pancreatitis group in terms of parenchymal necrosis and hemorrhage scores (P = 0.007, P = 0.002, and P = 0.052, respectively). No statistically significant differences were found in serum level of amylase, lipase, pancreatic myeloperoxidase activity and the other histopathological scores (P > 0.05). Conclusion: Diclofenac sodium, a cost-effective agent with a favorable side-effect profile, may represent a novel therapeutic agent for the treatment of acute pancreatitis. Findings of this study suggest a better efficacy for diclofenac sodium monotherapy as compared to octreotide alone or octreotide/diclofenac combination.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Project Granten_US
dc.description.sponsorshipOur sources of financial support are provided by Necmettin Erbakan University Scientific Project Grant.en_US
dc.identifier.endpage17564en_US
dc.identifier.issn1940-5901
dc.identifier.issue10en_US
dc.identifier.pmid26770346en_US
dc.identifier.scopus2-s2.0-84949684351en_US
dc.identifier.startpage17551en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17768
dc.identifier.volume8en_US
dc.identifier.wosWOS:000367669800054en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiclofenac Sodiumen_US
dc.subjectOctreotideen_US
dc.subjectExperimental Acute Pancreatitisen_US
dc.titleEffects of diclofenac sodium and octreotide on treatment of caerulein-induced acute pancreatitis in miceen_US
dc.typeArticleen_US

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