The pattern of neural tube defects in a highly endogamous society: A 25-year incidence trends

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dc.contributor.authorBener, Abdulbari
dc.contributor.authorKurdi, Bader
dc.contributor.authorHoffmann, Georg F.
dc.contributor.authorCaksen, Huseyin
dc.contributor.authorTeebi, Ahmad
dc.date.accessioned2024-02-23T14:34:45Z
dc.date.available2024-02-23T14:34:45Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractThe wide variety in incidence rates of neural tube defects (NTD) in the Arabian region have been attributed to environmental, dietary and genetic factors. No previous study has been conducted in the State of Qatar to document the incidence and trends of NTD. The aim of this study is to determine the incidence and trends of NTD over a period of 25 yr in the State of Qatar. This is a retrospective hospital based cohort study. The survey was carried out in the main territory hospital in the State of Qatar. The study was conducted from 1985 to 2009 with a total of 302,049 newborns at the Women's Hospital in Qatar screened for NTD. NTD were defined according to the International Classification of Diseases, Tenth Revision. Study parameters included age, gender, ethnicity, parental consanguinity, and residential area. The combined prevalence of NTD (total myelomeningocele and anencephaly) during the 25 yr period was 1.09 per 1,000 births. The prevalence of anencephaly was 0.36 per 1,000 births. There were 131 (42.1%) males and 180 (57.9%) female newborns with NTD, corresponding to incidence of 0.899 and 1.289 per 1,000 in male and female newborns, respectively. This difference was significant (P <0.001). Consanguinity was seen in 36.7% of the parents. The present study revealed that Qatar has a relatively low incidence of NTD, which is comparable to neighboring countries in the Arabian Gulf region. High rates of consanguinity and lack of periconceptual folic acid intake among mothers appear to be the major factors contributing to NTD in Qatar.en_US
dc.description.sponsorshipQatar National Research Fund - QNRF [UREP 08-090-3-018]; Hamad Medical Corporation [10146/10]en_US
dc.description.sponsorshipThis research project was generously supported and funded by the Qatar National Research Fund - QNRF UREP 08-090-3-018. The authors would like to thank the Hamad Medical Corporation for their support and ethical approval (HMC RP # 10146/10). The au thors would also like to thank Ms. Mariam Abdel-Hafiz for assistance in preparing and editing the manuscript.en_US
dc.identifier.doi10.3233/JPN-2012-0567
dc.identifier.endpage198en_US
dc.identifier.issn1304-2580
dc.identifier.issn1875-9041
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84865598844en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.3233/JPN-2012-0567
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15736
dc.identifier.volume10en_US
dc.identifier.wosWOS:000216255500005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIncidenceen_US
dc.subjectNeural Tube Defectsen_US
dc.subjectBirth Weighten_US
dc.subjectGestational Ageen_US
dc.subjectConsanguinityen_US
dc.subjectVitamin B12en_US
dc.subjectFolateen_US
dc.titleThe pattern of neural tube defects in a highly endogamous society: A 25-year incidence trendsen_US
dc.typeArticleen_US

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