How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?

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dc.contributor.authorDemir, Nazlim A.
dc.contributor.authorSumer, Sua
dc.contributor.authorCelik, Gulperi
dc.contributor.authorAfsar, Rengin E.
dc.contributor.authorDemir, Lutfi S.
dc.contributor.authorUral, Onur
dc.date.accessioned2024-02-23T14:24:17Z
dc.date.available2024-02-23T14:24:17Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBackground: Procalcitonin (PCT) and C-reactive protein (CRP) are used most widely in the diagnosis/treatment of bacterial infections. These are not infection-specific and may also show increases in other inflammation-causing cases. Aim: To establish a new cut-off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in haemodialysis (HD) patients. Methods: A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, was included in the study. Results: A total of 802 patients with undocumented infection had a mean CRP value of 12.2 +/- 9.6 mg/dL and a mean PCT value of 0.51 +/- 0.96 ng/mL and the 308 patients with documented infection had a mean CRP value of 125.9 +/- 83.3 mg/dL and a mean PCT value of 13.9 +/- 26.9 ng/mL at the time of admittance. In HD patients, the cut-off values for CRP was determined as 19.15 mg/dL and for PCT as 0.685 ng/mL in the presence of infection. The use of these two parameters in combination (CRP = 19.15 mg/dL and PCT = 0.685 ng/mL) was found to have 95% positive predictive value (PPV) and 93% negative predictive value (NPV) for the diagnosis of infectious diseases in HD patients. When CRP = 100 mg/dL and PCT = 5 ng/mL, this was found to have 100% PPV and 94% NPV for the diagnosis of sepsis in HD patients. Conclusion: We specified PCT and CRP cut-off values with high PPV and NPV for revealing the presence of bacterial infection and sepsis in HD patients.en_US
dc.identifier.doi10.1111/imj.13952
dc.identifier.endpage+en_US
dc.identifier.issn1444-0903
dc.identifier.issn1445-5994
dc.identifier.issue10en_US
dc.identifier.pmid29717808en_US
dc.identifier.scopus2-s2.0-85054338529en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1222en_US
dc.identifier.urihttps://doi.org/10.1111/imj.13952
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13889
dc.identifier.volume48en_US
dc.identifier.wosWOS:000446432500008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternal Medicine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Renal Failureen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectInfectionen_US
dc.subjectHaemodialysisen_US
dc.subjectProcalcitoninen_US
dc.titleHow should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?en_US
dc.typeArticleen_US

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