Possible neoplastic effects of acrylamide on rat exocrine pancreas

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dc.contributor.authorYener, Y.
dc.contributor.authorKalipci, E.
dc.contributor.authorOztas, H.
dc.contributor.authorAydin, A. D.
dc.contributor.authorYildiz, H.
dc.date.accessioned2024-02-23T14:34:37Z
dc.date.available2024-02-23T14:34:37Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractWe investigated whether the acrylamide formed during cooking carbohydrate-rich foods at high temperatures causes neoplastic changes in rat pancreas. Azaserine, which is an amino acid derivative that has the ability to initiate neoplastic changes in rat pancreas, was injected into 14-day-old male rats once a week for three weeks. Acrylamide was given to both azaserine-injected and non-injected rats at doses of 5 and 10 mg/kg/day in drinking water for 16 weeks after which tissue slides were prepared from the pancreata. Pancreas weights and body weights of rats treated with azaserine and acrylamide together increased significantly compared to the other groups. Moreover, the size, average diameter and volume of atypical acinar cell foci that developed in the pancreata of rats treated with azaserine and acrylamide together increased significantly compared to rats treated with either azaserine or acrylamide alone and control groups. Atypical acinar cell adenoma or adenocarcinoma was not observed in the pancreata of rats in any group.en_US
dc.description.sponsorshipSelcuk University [09401045]en_US
dc.description.sponsorshipWe express our thanks to Scientific Investigation Project to Coordinate of Selcuk University (Project No: 09401045) for financial support.en_US
dc.identifier.doi10.3109/10520295.2012.733028
dc.identifier.endpage53en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid23101568en_US
dc.identifier.scopus2-s2.0-84871435371en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.733028
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15670
dc.identifier.volume88en_US
dc.identifier.wosWOS:000321903200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectAtypical Acinar Cell Focien_US
dc.subjectCarcinogenesisen_US
dc.subjectPancreasen_US
dc.subjectRaten_US
dc.titlePossible neoplastic effects of acrylamide on rat exocrine pancreasen_US
dc.typeArticleen_US

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