Neuroprotective Effects of Tocilizumab on Experimentally-Induced Spinal Cord Ischemia-Reperfusion Injury

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dc.contributor.authorKaratas, Yasar
dc.contributor.authorErdi, Mehmet Fatih
dc.contributor.authorKaya, Bulent
dc.contributor.authorKeskin, Fatih
dc.contributor.authorCuce, Gokhan
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorUyar, Mehmet
dc.date.accessioned2024-02-23T14:16:29Z
dc.date.available2024-02-23T14:16:29Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVES: We aimed to evaluate neuroprotective effects of tocilizumab on spinal cord ischemia-reperfusion (I/R) injury. Our study design was an experimental rabbit spinal cord I/R injury model, and the setting was at the Animal Research Laboratory, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey. METHODS: Twenty-four adult New Zealand rabbits were randomly divided into 3 groups: Group 1, control group (n = 8); Group 2, I/R group, and Group 3 (n = 8) I/R injury D tocilizumab (4 mg/kg, ip) treatment group. Spinal cord I/R injury repair was performed by infrarenal aortic cross clamping. On neurologic evaluation, spinal cord tissue plasma tumor necrosis factor alpha (TNFa), total antioxidant status (TAS), total oxidant status (TOS), thiobarbituric acid reactive substances (TBARS), interleukin 6 (IL-6), interleukin 10 (IL-10) levels were analyzed. Spinal cord neuronal damage score and apoptotic cell count were also investigated. RESULTS: I/R injury significantly increases the plasma and spinal cord tissue TNFa, TOS, TBARS, and IL-6 levels and decreases the plasma and spinal cord tissue TAS and IL-10 levels. Tocilizumab treatment significantly reduces the plasma and spinal cord tissue TNF alpha, TOS, TBARS, IL-6 levels and increases plasma and tissue TAS and IL-10 levels. I/R injury significantly increases spinal cord neuronal damage score and apoptotic cell count. Tocilizumab treatment significantly reduces spinal cord neuronal damage score and apoptotic cell count. Neurologic examination scores at 24, 48, and 72 hours were significantly better in the treatment group when compared with the I/R group. CONCLUSIONS: This study shows significant neuroprotective effects of tocilizumab on rabbit spinal cord I/R injury.en_US
dc.identifier.doi10.1016/j.wneu.2018.12.069
dc.identifier.endpageE213en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid30593966en_US
dc.identifier.scopus2-s2.0-85060176751en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE208en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2018.12.069
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12673
dc.identifier.volume124en_US
dc.identifier.wosWOS:000463087800027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectNeuroprotectiveen_US
dc.subjectSpinalen_US
dc.subjectTocilizumaben_US
dc.titleNeuroprotective Effects of Tocilizumab on Experimentally-Induced Spinal Cord Ischemia-Reperfusion Injuryen_US
dc.typeArticleen_US

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