Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity

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dc.contributor.authorOzkur, E.
dc.contributor.authorKaradag, A. S.
dc.contributor.authorUstuner, P.
dc.contributor.authorAksoy, B.
dc.contributor.authorEsme, P.
dc.contributor.authorCaliskan, E.
dc.contributor.authorAkoglu, G.
dc.date.accessioned2024-02-23T14:24:02Z
dc.date.available2024-02-23T14:24:02Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.en_US
dc.identifier.doi10.1111/ced.14478
dc.identifier.endpage540en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue3en_US
dc.identifier.pmid33030217en_US
dc.identifier.scopus2-s2.0-85099097169en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage532en_US
dc.identifier.urihttps://doi.org/10.1111/ced.14478
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13794
dc.identifier.volume46en_US
dc.identifier.wosWOS:000604099200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical And Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleClinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severityen_US
dc.typeArticleen_US

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