Effect of serum uric acid on the positive predictive value of dobutamine stress echocardiography

Basit Öğe Kaydı
dc.contributor.authorAribas, Alpay
dc.contributor.authorAkilli, Hakan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAlibasic, Hayrudin
dc.contributor.authorYildirim, Oguzhan
dc.contributor.authorSertdemir, Ahmet Lutfi
dc.contributor.authorKaranfil, Mustafa
dc.date.accessioned2024-02-23T13:43:45Z
dc.date.available2024-02-23T13:43:45Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThere is controversial data regarding the relationship between uric acid (UA) and coronary artery disease and cardiovascular events. Despite the deleterious effects of hyperuricemia on endothelial function, the effect of UA on myocardial ischemia has not been previously studied. We aimed to investigate the relationship between UA and myocardial ischemia that was identified using dobutamine stress echocardiography (DSE). In this retrospective study, the laboratory and DSE reports of 548 patients were reviewed. The patients were divided into two groups based on the presence of ischemia and further subdivided into three groups according to the extent of ischemia (none, ischemia in 1-3 segments, ischemia in > 3 segments). Serum UA levels were compared. Determinants of ischemia were assessed using a regression model. UA was increased in patients with ischemia and was correlated with the number of ischemic segments (p < 0.001). A cutoff value of UA > 5 mg/dl had 63.9 % sensitivity, 62.0 % specificity, 42.5 % positive predictive value (PPV), and 79.6 % negative predictive value for ischemia. When the positive DSE exams were further sorted according to the UA cutoff, the PPV of DSE increased from 80.2 to 94.0 %. Uric acid (odds ratio 1.51; 95 % CI 1.14-1.99), diabetes mellitus, HDL and glomerular filtration rate were found to be independent determinants of myocardial ischemia in DSE. Increased UA is associated with both the presence and extent of DSE-identified myocardial ischemia. A UA cutoff may be a good method to improve the PPV of DSE.en_US
dc.identifier.doi10.1007/s00380-014-0609-1
dc.identifier.endpage389en_US
dc.identifier.issn0910-8327
dc.identifier.issn1615-2573
dc.identifier.issue3en_US
dc.identifier.pmid25502950en_US
dc.identifier.scopus2-s2.0-84959470526en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.1007/s00380-014-0609-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10912
dc.identifier.volume31en_US
dc.identifier.wosWOS:000371803600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHeart And Vesselsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDobutamine Stress Echocardiographyen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectUric Aciden_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectHyperuricemiaen_US
dc.titleEffect of serum uric acid on the positive predictive value of dobutamine stress echocardiographyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu