The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

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dc.contributor.authorSoyuduru, Gonca
dc.contributor.authorOzsoy Adisen, Esra
dc.contributor.authorKadioglu Ozer, Ilkay
dc.contributor.authorAksakal, A. Burhan
dc.date.accessioned2024-02-23T14:37:23Z
dc.date.available2024-02-23T14:37:23Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. Materials and methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. Results: In AV patients, pretreatment HOMA-IR and adipocytokine levels were not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values were found (P = 0.028). Isotretinoin therapy maintained lower mean resistin levels (P = 0.016), higher mean RBP4 levels (P = 0.040), but not affected the mean adiponectin and leptin levels (P = 0.113, P = 0.125, respectively). Conclusions: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in insulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients.en_US
dc.identifier.doi10.3906/sag-1806-44
dc.identifier.endpage244en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid30761880en_US
dc.identifier.scopus2-s2.0-85061574285en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1806-44
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16080
dc.identifier.volume49en_US
dc.identifier.wosWOS:000458367000034en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectAdipocytokineen_US
dc.subjectInsulin Sensitivityen_US
dc.titleThe effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patientsen_US
dc.typeArticleen_US

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