Investigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adults

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dc.contributor.authorAftabi, Younes
dc.contributor.authorAmiri-Sadeghan, Amir
dc.contributor.authorGilani, Neda
dc.contributor.authorBakhtiyari, Nasim
dc.contributor.authorAnsarin, Atefeh
dc.contributor.authorSharifi, Akbar
dc.contributor.authorAnsarin, Khalil
dc.date.accessioned2024-02-23T14:49:30Z
dc.date.available2024-02-23T14:49:30Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAryl hydrocarbon Receptor (AhR) is a ligand-activated transcription factor with an important role in lung health. The association of AhR polymorphisms with asthma severity has not been yet investigated. We analyzed the association of G1661A, the most prevalent polymorphism of AhR, with the asthma stages in a population-based study including 555 asthmatics (Intermittent: 93, Mild: 240, Moderate: 158, and Severe: 64). The SNP was genotyped using allele-specific PCR. Obtained data were analyzed using the Generalized-Ordered Logit Estimates. Genotypes GA (OR: 0.53, CI: 0.32-0.90, P=0.019) and AA (OR: 0.22, CI: 0.06-0.76, P=0.017) were associated with decreased risk of Severe, Moderate, Mild vs. Intenaittent stage; and Severe, Moderate, vs. Mild, Intermittent stages respectively. However, Genotype GA (OR: 1.90, CI: 1.05-3.44, P=0.033), dominant model GA+AA (OR: 2.04, CI: 1.17-3.57, P=0.012), and allele A (OR: 1.68, CI: 1.06-2.66, P=0.027) were associated with increased risk of Severe stage vs. Moderate, Mild, Intermittent stages. Also, male sex and higher age were associated with an increased odds ratio for severe asthma. Furthermore, significant associations with asthma stages were found for the interactions of the SNP and sex, smoking, and alcohol consumption. In conclusion, we revealed that the mutant allele of AhR-G1661A may interact with independent variables and act as a protective factor against lower stages of asthma but it may increase the risk of severe asthma.en_US
dc.description.sponsorshipTuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [64728]en_US
dc.description.sponsorshipThis study was funded by the Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran (Grant no: 64728) . The study protocol was approved by the research ethics committee of the Tabriz University of Medical Sciences (IR.TBZMED.REC.1399.700) and all contributors gave written informed consent.en_US
dc.identifier.endpage319en_US
dc.identifier.issn0301-1208
dc.identifier.issn0975-0959
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85127675835en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18233
dc.identifier.volume59en_US
dc.identifier.wosWOS:000778460800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal Of Biochemistry & Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAhr Geneen_US
dc.subjectLung Diseasesen_US
dc.subjectGenetic Associationen_US
dc.subjectRs2066853en_US
dc.subjectPolymorphismen_US
dc.titleInvestigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adultsen_US
dc.typeArticleen_US

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