The effect of intrathecal sufentanil preconditioning against myocardial ischemia-reperfusion injury

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dc.contributor.authorTire, Y.
dc.contributor.authorSarkilar, G.
dc.contributor.authorEsen, H.
dc.contributor.authorOnoglu, R.
dc.contributor.authorUzun, S. T.
dc.date.accessioned2024-02-23T14:37:59Z
dc.date.available2024-02-23T14:37:59Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVES: We aimed to investigate the cardioprotective effect and hemodynamic response of intrathecally administered sufentanil on myocardial IR injury. BACKGROUND: Sufentanil, mu opioid receptor agonist, intravenously administered during clinical and experimental studies, has been shown to have a cardioprotective effect on myocardial ischemia-reperfusion injury. METHODS: Thirty-two New Zealand type rabbits, which were anesthetized, were divided into four equal groups: sham, ischemia-reperfusion, sufentanil and ischemia-reperfusion+sufentanil. Sufentanil was administered intrathecally prior to ischemia. Hemodynamic parameters were monitored by electrocardiography and invasive arterial blood pressure measurements. In the ischemia-reperfusion groups, the degree of myocardial infarct was determined as the ratio of ischemic region to the risk area by a 1 % 2,3,5-triphenyl tetrazolium chloride staining. RESULTS: The mean infarct size in the ischemia-reperfusion group was 47.5 +/- 7.0 %, whereas that of the ischemia-reperfusion+sufentanil group was found to be 34.2 +/- 4.7 %, indicating a statistically signifi cant difference (p = 0.002). The heart rate was different between the ischemia-reperfusion and the sufentanil groups for baseline measurement and between the ischemia-reperfusion and the ischemia-reperfusion+sufentanil groups at the 120th minutes measurement (p < 0.05). CONCLUSION: Intrathecal sufentanil appears to have a cardioprotective effect against myocardial ischemia-reperfusion injury in the experimental rabbit model (Tab. 1, Fig. 2, Ref. 19). Text in PDF www. elis. sk.en_US
dc.identifier.doi10.4149/BLL_2018_045
dc.identifier.endpage244en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid29663822en_US
dc.identifier.scopus2-s2.0-85045034893en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_045
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16319
dc.identifier.volume119en_US
dc.identifier.wosWOS:000431141900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntrathecal Sufentanilen_US
dc.subjectPreconditioningen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectReperfusionen_US
dc.subjectInfarct Sizeen_US
dc.subjectHemodynamicen_US
dc.titleThe effect of intrathecal sufentanil preconditioning against myocardial ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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