How extracellular sodium replacement affects the conduction velocity distribution of rats' peripheral nerves

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dc.contributor.authorTuncer, S.
dc.contributor.authorCelen, M. C.
dc.date.accessioned2024-02-23T14:29:36Z
dc.date.available2024-02-23T14:29:36Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIn electrophysiological studies, the substitution of Na+ is used as a method in the extracellular environment. N-methyl-D-glucamine (megulamine; NMG) is an excipient because of its pharmacologically inactive nature, which can block the Na currents at a cellular level. In this study, we investigated alterations in the contributions of fiber groups to compound action potential (CAP) during NMG replacement. The replacement resulted in a significant decrease in both the amplitude and the area of the CAP for each replacement group. Full replacement did not decrease the CAP area compared to partial replacement. Different replacement ratios of Na+ in the extracellular medium with NMG have been shown to cause changes in the activities of some nerve fibers, as well as blocking the conduction. The findings were obtained by the specific distribution of the nerve conduction velocity calculation method. The partial replacement of extracellular Na affects the fast-conducting fiber groups, whereas full replacement affects the slow-conducting fiber groups.en_US
dc.identifier.doi10.14735/amcsnn2019209
dc.identifier.endpage214en_US
dc.identifier.issn1210-7859
dc.identifier.issn1802-4041
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85069698979en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.14735/amcsnn2019209
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14754
dc.identifier.volume82en_US
dc.identifier.wosWOS:000462991800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCzech Medical Socen_US
dc.relation.ispartofCeska A Slovenska Neurologie A Neurochirurgieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAction Potentialen_US
dc.subjectNerve Conduction Velocity Distributionen_US
dc.subjectN-Metyl-D-Glucamineen_US
dc.subjectPeripheral Nerveen_US
dc.titleHow extracellular sodium replacement affects the conduction velocity distribution of rats' peripheral nervesen_US
dc.typeArticleen_US

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