Relationship of preoperative neutrophil lymphocyte ratio with prognosis in gastrointestinal stromal tumors

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dc.contributor.authorKargin, Suleyman
dc.contributor.authorCakir, Murat
dc.contributor.authorGundes, Ebubekir
dc.contributor.authorYavuz, Yusuf
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorIyisoy, M. Sinan
dc.contributor.authorKokbudak, Naile
dc.date.accessioned2024-02-23T14:41:20Z
dc.date.available2024-02-23T14:41:20Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjective: Gastrointestinal stromal tumors are believed to play a role in immunosuppression with their local effect. In some cancers with associated inflammation, an increased pretreatment neutrophil lymphocyte ratio is considered as an indicator of poor prognosis. The aim of our study was to assess the relationship of increased blood neutrophil lymphocyte ratio with disease prognosis in patients with gastrointestinal stromal tumors. Material and Methods: The data of 78 patients who underwent surgery with the diagnosis of primary gastrointestinal stromal tumor in our clinic were evaluated retrospectively. The preoperative neutrophil lymphocyte ratio in the peripheral blood was determined. The neutrophil lymphocyte ratio and its relationship with tumor risk and prognosis were compared. The data were evaluated by Pearson's correlation analysis and the Welch ANOVA test. Results: The preoperative neutrophil lymphocyte ratio was significantly increased in the high-risk groups (p<0.05). An increased preoperative neutrophil lymphocyte ratio was associated with shorter survival (r=-0.32, p=0.009). In addition, an increase in the neutrophil lymphocyte ratio was associated with an increase in the mitotic activity of the tumor (r=-0.364, p=0.025). Conclusion: The preoperative neutrophil lymphocyte ratio in gastrointestinal stromal tumors can be used as an indicator of high-risk tumors and poor prognosis.en_US
dc.identifier.doi10.5152/UCD.2015.2840
dc.identifier.endpage64en_US
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue2en_US
dc.identifier.pmid26170750en_US
dc.identifier.scopus2-s2.0-84931864610en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.5152/UCD.2015.2840
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16815
dc.identifier.volume31en_US
dc.identifier.wosWOS:000370846200002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Surgical Assocen_US
dc.relation.ispartofTurkish Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastrointestinal Stromal Tumoren_US
dc.subjectNeutrophil Lymphocyte Ratioen_US
dc.subjectPrognosisen_US
dc.titleRelationship of preoperative neutrophil lymphocyte ratio with prognosis in gastrointestinal stromal tumorsen_US
dc.typeArticleen_US

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