Anticancer mechanism of Sinapic acid in PC-3 and LNCaP human prostate cancer cell lines

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dc.contributor.authorEroglu, Canan
dc.contributor.authorAvci, Ebru
dc.contributor.authorVural, Hasibe
dc.contributor.authorKurar, Ercan
dc.date.accessioned2024-02-23T14:02:58Z
dc.date.available2024-02-23T14:02:58Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractSinapic acid (SA) is a derivative of hydroxycinnamic acid and found in various vegetables and fruit species. Aim was to evaluate the anticancer effects of SA in PC-3 and LNCaP human prostate cancer cells. The effect of SA on cell viability was determined using XTT assay. Expressions of 8 genes for apoptosis and 6 genes for metastasis were evaluated by qPCR. Caspase-3 activity was determined using caspase-3 colorimetric assay kit. Effect of SA on cell invasion was evaluated with cell invasion assay. The IC50 dose of SA in PC-3 and LNCaP cells was found to be 1000 mu M for 72 h. SA treatment increased the expression of BAX, CASP3, CASP8, CYCS, FAS, TIMP-1 and CDH1 however significantly decreased the expression of MMP-9 in PC-3 cells. In LNCaP cells, the expressions of BAX, CASP3, CASP7 and CYCS were significantly elevated; however, a decrease was seen in the expressions of CDH2, MMP-2 and MMP-9 in the SA treatment. Moreover, SA significantly increased caspase-3 activity and suppressed the cell invasion. In conclusion, it is thought that SA has anticancer effect on prostate cancer cells. However, more detailed studies should be conduct to illuminate molecular mechanism of apoptotic and anti metastatic activity of SA.en_US
dc.description.sponsorshipNecmettin Erbakan University, Scientific Research Projects [151218023]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University, Scientific Research Projects (#151218023).en_US
dc.identifier.doi10.1016/j.gene.2018.05.049
dc.identifier.endpage134en_US
dc.identifier.issn0378-1119
dc.identifier.issn1879-0038
dc.identifier.pmid29792952en_US
dc.identifier.scopus2-s2.0-85047989479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1016/j.gene.2018.05.049
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11923
dc.identifier.volume671en_US
dc.identifier.wosWOS:000439672400015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectInvasionen_US
dc.subjectProstate Canceren_US
dc.subjectSinapic Aciden_US
dc.titleAnticancer mechanism of Sinapic acid in PC-3 and LNCaP human prostate cancer cell linesen_US
dc.typeArticleen_US

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