Pediatric Carbon Monoxide Poisoning Effects of Hyperbaric Oxygen Therapy on Thiol/Disulfide Balance

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dc.contributor.authorBagci, Zafer
dc.contributor.authorArslan, Abdullah
dc.contributor.authorNeselioglu, Salim
dc.date.accessioned2024-02-23T14:21:17Z
dc.date.available2024-02-23T14:21:17Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjectives Carbon monoxide (CO) poisoning remains the foremost cause of poisoning worldwide. This study aimed to investigate the effects of hyperbaric oxygen therapy (HBOT) and normobaric oxygen therapy (NBOT) on thiol/disulfide homeostasis in children with CO intoxication. Methods Eighty-one children aged 0 to 18 years with CO intoxication were included in this cross-sectional study. No changes were made in the routine clinical evaluation and treatment practices of the patients. Thirty-two children who received HBOT and 49 children who received NBOT were compared for serum native thiol, disulfide, and total thiol levels, as well as for the changes in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios before and after treatment. Results Antioxidant levels, such as native thiol and total thiol, were significantly decreased in patients who received HBOT and increased in those who received NBOT (P = 0.02 and P = 0.01, respectively). There was no statistically significant difference between the 2 groups concerning the change of native thiol/total thiol ratios (P = 0.07). In addition, there was no significant difference regarding changes in disulfide, disulfide/native thiol, and disulfide/total thiol levels before and after treatment (P = 0.39, P = 0.07, and P = 0.07, respectively). Conclusions Although thiol-disulfide balance is maintained in patients treated with HBOT, antioxidant levels decrease significantly compared with NBOT. Despite efficiency of HBOT in CO intoxication, oxidative stress and reperfusion injury due to hyperoxygenation should be considered in the treatment of HBOT.en_US
dc.identifier.doi10.1097/PEC.0000000000002619
dc.identifier.endpage107en_US
dc.identifier.issn0749-5161
dc.identifier.issn1535-1815
dc.identifier.issue3en_US
dc.identifier.pmid35226618en_US
dc.identifier.scopus2-s2.0-85125679443en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.1097/PEC.0000000000002619
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13533
dc.identifier.volume38en_US
dc.identifier.wosWOS:000761960200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPediatric Emergency Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon Monoxide Poisoningen_US
dc.subjectThiol-Disulfideen_US
dc.subjectOxidative Stressen_US
dc.titlePediatric Carbon Monoxide Poisoning Effects of Hyperbaric Oxygen Therapy on Thiol/Disulfide Balanceen_US
dc.typeArticleen_US

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