Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

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dc.contributor.authorCakir, Ozlem Ozer
dc.contributor.authorFindik, Siddika
dc.date.accessioned2024-02-23T14:26:33Z
dc.date.available2024-02-23T14:26:33Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractAim. We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods. A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results. Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0 001, P < 0 001, P < 0 001, P < 0 001, and P = 0 048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P < 0 001, P < 0 001, P < 0 001, P = 0 030, and P < 0 001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P = 0 008, P = 0 014, and P < 0 001, respectively); and mean congestion and hydropic degeneration scores in the liver (P = 0 029 and P = 0 002, respectively). Conclusion. Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis.en_US
dc.identifier.doi10.1155/2018/9829208
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.pmid30515205en_US
dc.identifier.scopus2-s2.0-85062848760en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2018/9829208
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14243
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000449871200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofGastroenterology Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleDiclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caeruleinen_US
dc.typeArticleen_US

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