Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP

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dc.contributor.authorDodurga, Yavuz
dc.contributor.authorEroglu, Canan
dc.contributor.authorSecme, Mucahit
dc.contributor.authorElmas, Levent
dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorSatiroglu-Tufan, N. Lale
dc.date.accessioned2024-02-23T14:00:02Z
dc.date.available2024-02-23T14:00:02Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractFerulic acid (4-hydroxy-3-methoxycinnamic acid; FA), a common dietary plant phenolic compound, is abundant in fruits and vegetables. The aim of present study is to investigate the effects of FA on cell cycle, apoptosis, invasion, migration, and colony formation in the TT medullary thyroid cancer cell line. The effect of FA on cell viability was determined by using CellTiter-Glo assay. IC50 dose in the TT cells was detected as 150 mu M. URG4/URGCP (upregulated gene-4/upregulator of cell proliferation) is a novel gene in full-length mRNA of 3.607 kb located on 7p13. It was determined that FA caused a decrease in the expression of novel gene URG4/URGCP, CCND1, CDK4, CDK6, BCL2, MMP2, and MMP9, a significant increase in the expression of p53, PARP, PUMA, NOXA, BAX, BID, CASP3, CASP9, and TIMP1 genes in TT human thyroid cancer cell line by using real-time PCR. It was found that FA in TT cells suppressed invasion, migration, and colony formation by using matrigel invasion chamber, wound healing, and colony formation assay, respectively. In conclusion, it is thought that FA indicates anticarcinogenesis activity by affecting cell cycle arrest, apoptosis, invasion, migration, and colony formation on TT cells.en_US
dc.identifier.doi10.1007/s13277-015-3984-z
dc.identifier.endpage1940en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue2en_US
dc.identifier.pmid26334619en_US
dc.identifier.scopus2-s2.0-84940706021en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1933en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-015-3984-z
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11431
dc.identifier.volume37en_US
dc.identifier.wosWOS:000374593300060en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFerulic Aciden_US
dc.subjectThyroid Canceren_US
dc.subjectTt Cellsen_US
dc.subjectUrg4/Urgcpen_US
dc.titleAnti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCPen_US
dc.typeArticleen_US

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